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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9104 | TJ191 | Apoptosis | |
TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells. | |||
T9715 | Aplidine | SARS-CoV , DNA/RNA Synthesis | |
Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM). Aplidine is a potent anti-cancer agent by targeting eukaryotic translation elongation factor 1 Alpha 2(EEF1A2, Kd = 80 nM). | |||
T6603 | Nelarabine | GW 506U78,Nelzarabine,506U78 | Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis |
Nelarabine (GW 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. | |||
T1511 | Daunorubicin hydrochloride | Daunomycin HCl,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin | Apoptosis , DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic , Autophagy |
Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein synthesis. | |||
T35569 | CTA 056 | Apoptosis | |
CTA 056 is an interleukin-2 induced T cell kinase (ITK) inhibitor, inhibits the growth of MOLT-4 xenograft tumors in mice, induces apoptosis in Jurkat cells, and can be used in the study of autoimmune disorders and T cel... | |||
T41163 | ZNL 02-096 | Pomalidomide-C3-adavosertib | Apoptosis , Wee1 |
ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL ... | |||
TN2755 | 2-Desoxy-4-epi-pulchellin | Anti-infection | |
2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows sig... | |||
T17225 | Vercirnon | CCX282-B,GSK-1605786,Traficet-EN | CCR |
Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases. | |||
T6748 | A-1155463 | A 1155463,A1155463 | BCL |
A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM). | |||
T2383 | Panobinostat | NVP-LBH589,LBH589 | Apoptosis , HIV Protease , HDAC , Autophagy |
Panobinostat (NVP-LBH589) is a broad-spectrum HDAC inhibitor (IC50=5 nM) with oral activity and non-selectivity. Panobinostat has antitumor activity and induces apoptosis and autophagy. | |||
T83561 | (2S)-4'-Hydroxy-7-methoxyflavan | ||
(2S)-4'-Hydroxy-7-methoxyflavan, a flavan, demonstrated significant cytotoxic effects on human leukemic Molt 4 cells [1]. | |||
TN4837 | Pseudotaraxasterol | AChR | |
Pseudotaraxasterol shows cytotoxic activity against MOLT-4 cells. | |||
T35476 | BSJ-04-132 | ||
Selective Cdk4 degrader. Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation. Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4... | |||
T39909 | XZ739 | XZ739 | |
XZ739 is a Cereblon-dependent PROTAC BCL-XL degrader, targeting a member of the Bcl-2 family, with a DC50 value of 2.5 nM in MOLT-4 cells after 16 hours of treatment. Additionally, XZ739 elicits cell death via caspase-me... | |||
T79451 | WES-1 | Carbonic Anhydrase | |
WES-1 (Compound 8g), a carbonic anhydrase IX inhibitor (Ki: 55.9 μM), exhibits broad-spectrum antiproliferative activity against various cancer cell lines, including leukemia (K-562 and MOLT-4), non-small cell lung cance... | |||
T35810 | C24 dihydro Ceramide (d18:0/24:0) | Cer(d18:0/24:0) | |
C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively c... | |||
T41016 | Vercirnon sodium | GSK-1605786 sodium,CCX282-Bsodium,Traficet-ENsodium | |
Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent CCR9 antagonist. It effectively inhibits CCR9-mediated calcium mobilization and chemotaxis in Molt-4 cells, exhibiting IC50 values of 5.4 nM... | |||
T37560 | Nidulin | ||
Nidulin is a depsidone originally isolated from A. nidulans. It is active against the bacteria M. tuberculosis and M. ranoe, as well as the fungi T. tonsurans and M. audouini. It also inhibits the growth of methicillin-r... | |||
T36894 | 5-Bromouridine | ||
5-Bromouridine is a brominated analog of the nucleoside uridine .1It can be incorporated into RNA and subsequently detected by antibodies against bromodeoxyuridine .25-Bromouridine decreases the viability of HL-60 and MO... | |||
T37419 | Zetomipzomib | ||
KZR-616, a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome. KZR-616 has the potential f... |