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C24 dihydro Ceramide (d18:0/24:0)

Catalog No. T35810 CAS 6063-36-1

Synonyms: Cer(d18:0/24:0)

C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively correlate with cytotoxicity in CCRF-CEM, MOLT-4, COG-LL-317h, and COG-LL-332h T cell acute lymphoblastic leukemia (ALL) cell lines.[4] Levels of C24 dihydro ceramide are increased by 149.49-fold in dihydroceramide desaturase 1 (DEGS1) knockdown UM-SCC-22A human head and neck squamous carcinoma cells in vitro.[4] C24 dihydro Ceramide levels are also increased in INS-1 β-cells incubated with glucose and palmitate.[5]

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C24 dihydro Ceramide (d18:0/24:0) Chemical Structure

C24 dihydro Ceramide (d18:0/24:0), CAS 6063-36-1

Pack Size	Availability	Price/USD
5 mg	Inquiry	$ 114.00
10 mg	Inquiry	$ 200.00
25 mg	Inquiry	$ 450.00
50 mg	Inquiry	$ 802.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Cer(d18:0/24:0)
Molecular Weight	652.146
Formula	C42H85NO3
CAS No.	6063-36-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMF: 0.15 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Farwanah, H., Wohlrab, J., Neubert, R.H., et al. Profiling of human stratum corneum ceramides by means of normal phase LC/APCI-MS. Anal. Bioanal. Chem. 383(4), 632-637 (2005). 2. Agrawal, K., Hassoun, L.A., Foolad, N., et al. Effects of atopic dermatitis and gender on sebum lipid mediator and fatty acid profiles. Prostaglandins Leukot. Essent. Fatty Acids 134, 7-16 (2018). 3. Holliday, M.W., Jr., Cox, S.B., Kang, M.H., et al. C22:0- and C24:0-dihydroceramides confer mixed cytotoxicity in T-cell acute lymphoblastic leukemia cell lines. PLoS One 8(9), (2013). 4. Breen, P., Jospeh, N., Thompson, K., et al. Dihydroceramide desaturase knockdown impacts sphingolipids and apoptosis after photodamage in human head and neck squamous carcinoma cells. Anticancer Res. 33(1), 77-84 (2013). 5. Véret, J., Coant, N., Berdyshev, E.V., et al. Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in gluco-lipotoxicity-induced apoptosis of INS-1 β-cells. Biochem J. 438(1), 177-189 (2011).

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

C24 dihydro Ceramide (d18:0/24:0) 6063-36-1 C-24 dihydro Ceramide (d18:0/24:0) Cer(d18:0/24:0) inhibitor inhibit

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