gsk3β — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21956	GSK3β inhibitor II		GSK-3
	GSK3β inhibitor II is a GSK3β inhibitor. GSK3β inhibitor II exhibits the research potential of Alzheimer's disease (AD).		GSK-3
T36088	GSK3β Inhibitor XI	GSK3β Inhibitor XI
	GSK3β Inhibitor XI has GSK3β inhibitory effect.
T63851	CDK9/10/GSK3β-IN-1
	CDK9/10/GSK3β-IN-1 is a kinase inhibitor (Flavopiridol analogue) that effectively inhibits HsGSK3β, HsCDK9/CyclinT, HsCDK5/p25 and HsCDK2/CyclinA with IC50 values of 59 nM, 64 nM, 1.093 μM and 1.725 μM, respectively. CDK...
T62719	AChE/BACE1/GSK3β-IN-1
	AChE/BACE1/GSK3β-IN-1 is an orally active, blood-brain barrier-transparent, moderately bioavailable triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 can be used to study Alzheimer's disease (AD).
T35556	GSK-3β inhibitor 8	GSK3β Inhibitor XVIII	GSK-3 , Wnt/beta-catenin
	GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine derivative that negatively regulates the Wnt signaling pathway an...		GSK-3 , Wnt/beta-catenin
T35554	GSK-3β inhibitor 3		Apoptosis , GSK-3
	GSK-3β inhibitor 3 is a covalent inhibitor (IC50: 6.6 μM) of glycogen synthase kinase 3β (GSK-3β) that is potent, selective, and irreversible.GSK-3β inhibitor 3 can be used to study acute promyelocytic leukemia.		Apoptosis , GSK-3
T39341	FCPR03		PDE
	FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr...		PDE
T2423	P7C3-A20		Others
	P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.		Others
T22012	7BIO		FLT , DYRK , Aurora Kinase
	7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases.		FLT , DYRK , Aurora Kinase
T11467	GSK-3β inhibitor 1		GSK-3
	GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.		GSK-3
T2P2810	Methyl Linoleate	Linoleic acid methyl ester,Telfairic Acid methyl ester	Antioxidant
	Methyl Linoleate (Telfairic Acid methyl ester) linoleate has antioxidant activity.		Antioxidant
T8376	PKCβ inhibitor 1	KUN79359	Apoptosis , PKC
	PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively).		Apoptosis , PKC
T11471	GSK-3β inhibitor 2	5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-	GSK-3
	GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50 = 1.1 nM). GSK-3β inhibitor 2 can be used in studies about Al...		GSK-3
T9178	(E/Z)-GSK-3β inhibitor 1	GSK-3β inhibitor 1	GSK-3
	(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.		GSK-3
T8605	GS87	4-[5-[[(3-Phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine	GSK-3
	GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.		GSK-3
T1764	Adezmapimod	PB 203580,RWJ 64809,SB203580	Mitophagy , p38 MAPK , Autophagy
	Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive. Adezmapimod possesses autophagy and mitochondrial autophagy activating activity. Adezmapimod displays more than 100...		Mitophagy , p38 MAPK , Autophagy
T1881	AR-A014418	AR 0133418,GSK-3beta Inhibitor VIII,AR 014418,GSK 3β inhibitor VIII	GSK-3
	AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.		GSK-3
T9025	KY19382	2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382,A3051	Others , GSK-3 , Wnt/beta-catenin
	KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382) is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β( IC50s of 19 and 10 nM, respectively). It...		Others , GSK-3 , Wnt/beta-catenin
T5200	Indirubin-3'-monoxime	Indirubin-3'-oxime	GSK-3 , Lipoxygenase , CDK
	Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).		GSK-3 , Lipoxygenase , CDK
T17019	TCS 21311	NIBR3049	GSK-3 , JAK , PKC
	TCS 21311 (NIBR3049) is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, respectively). It displays >100-fold selectivity over JAK1, JAK...		GSK-3 , JAK , PKC