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GSK-3β inhibitor 3

Catalog No. T35554 CAS 1448990-73-5

GSK-3β inhibitor 3 is a covalent inhibitor (IC50: 6.6 μM) of glycogen synthase kinase 3β (GSK-3β) that is potent, selective, and irreversible.GSK-3β inhibitor 3 can be used to study acute promyelocytic leukemia.

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GSK-3β inhibitor 3, CAS 1448990-73-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
5 mg	In stock	$ 247.00
10 mg	In stock	$ 393.00
25 mg	In stock	$ 659.00
50 mg	In stock	$ 939.00
100 mg	In stock	$ 1,270.00
500 mg	In stock	$ 2,550.00
1 mL * 10 mM (in DMSO)	In stock	$ 272.00

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Purity: 97.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GSK-3β inhibitor 3 is a covalent inhibitor (IC50: 6.6 μM) of glycogen synthase kinase 3β (GSK-3β) that is potent, selective, and irreversible.GSK-3β inhibitor 3 can be used to study acute promyelocytic leukemia.
Targets&IC50	GSK-3β:6.6 μM (IC50)
In vitro	GSK-3β inhibitor 3 (compound 4-3) (6.25-100 μM; 24-48 h) dose-dependently inhibited the cell viability, with IC50s of 19.56 μM and 26.42 μM in NB4 and NB4-R1 cells at 24 h, respectively. GSK-3β inhibitor 3 (12.5-100 μM; 24 h) significantly increases the percentage of apoptosis in a dose-dependent pattern in NB4 and NB4-R1 cells.[1] GSK-3β inhibitor 3 (100 μM) inhibits GSK-3α activity by 87.3%.[1]
In vivo	GSK-3β inhibitor 3 (compound 4-3) (15 mg/kg; a single i.p.; Balb/c female nude mice) shows T1/2 value 14.2 h, AUC values (AUClast=3503.42 ng/mL•h), and maximum concentration (Cmax=515 ng/mL) in mice.[1] GSK-3β inhibitor 3 (15 mg/kg/d; i.p. for 2 weeks; Balb/c female nude mice) inhibits tumor growth of mice by 75.97% relative to vehicle control.[1]

Molecular Weight	327.37
Formula	C18H14FNO2S
CAS No.	1448990-73-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (687.3 mM), Sonication is recommended.

References and Literature

1. Zhang P, et al. Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3β Inhibitors for the Treatment of Acute Promyelocytic Leukemia. J Med Chem. 2021;64(11):7341-7358.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Kinase Inhibitor Library Anti-Cancer Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GSK-3β inhibitor 3 1448990-73-5 Apoptosis PI3K/Akt/mTOR signaling Stem Cells GSK-3 GSK-3beta inhibitor 3 GSK3β inhibitor 3 GSK 3β inhibitor 3 GSK-3b inhibitor 3 inhibitor inhibit

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