Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine derivative that negatively regulates the Wnt signaling pathway and stimulates β-cell proliferation.
Pack Size | Availability | Price/USD | Quantity |
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1 mg | 35 days | $ 110.00 |
Description | GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine derivative that negatively regulates the Wnt signaling pathway and stimulates β-cell proliferation. |
In vitro |
GSK-3β inhibitor 8 (Compound 1a) (1 nM-100 μM; 7 d) dose-dependently stimulates β-cell proliferation with an EC50 value of 1.41 μM. GSK-3β inhibitor 8 (2 μM; 72 h) increases replicating R7T1 β cells approximately 2-fold.[1] GSK-3β inhibitor 8 (1 nM-100 μM; 24 h) induces activation of the Super (8X) TOPFlash reporter with an EC50 value of 1.25 μM.[1] GSK-3β inhibitor 8 (2 μM; 72 h) stimulates β-catenin translocation into the nucleus in HEK293 cells.[1] |
Synonyms | GSK3β Inhibitor XVIII |
Molecular Weight | 413.92 |
Formula | C20H20ClN5OS |
CAS No. | 1139875-74-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
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GSK-3β inhibitor 8 1139875-74-3 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Stem Cells Wnt/beta-catenin GSK-3 GSK3β Inhibitor XVIII GSK-3b inhibitor 8 GSK3b Inhibitor XVIII GSK-3beta inhibitor 8 GSK3beta Inhibitor XVIII inhibitor inhibit