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KY19382

Catalog No. T9025 CAS 2226664-93-1

Synonyms: 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382, A3051

KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382) is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β( IC50s of 19 and 10 nM, respectively). It activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

KY19382, CAS 2226664-93-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 100.00
5 mg	In stock	$ 207.00
10 mg	In stock	$ 369.00
25 mg	In stock	$ 622.00
50 mg	In stock	$ 885.00
100 mg	In stock	$ 1,190.00
500 mg	In stock	$ 2,430.00
1 mL * 10 mM (in DMSO)	In stock	$ 255.00

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Purity: 98.06%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

CXXC5-DVL:10 nM, GSK-3β:10 nM

Synonyms	2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382, A3051
Molecular Weight	360.19
Formula	C17H11Cl2N3O2
CAS No.	2226664-93-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (13.88 mM), Sonification is recommended.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Anti-Lung Cancer Compound Library Anti-Pancreatic Cancer Compound Library Stem Cell Differentiation Compound Library Anti-Cancer Compound Library Anti-Liver Cancer Compound Library Oxidation-Reduction Compound Library Anti-Breast Cancer Compound Library

Related Products

Related compounds with same targets

Neogrifolin 9-ING-41 LY2090314 Laduviglusib trihydrochloride PF-04802367 Ginsenoside Rg2 GSK-3β inhibitor 2 RGB-286638 free base

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KY19382 2226664-93-1 Cytoskeletal Signaling Others PI3K/Akt/mTOR signaling Stem Cells Wnt/beta-catenin GSK-3 Glycogen synthase kinase 3 KY 19382 Beta catenin β-catenin 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382 inhibit Wnt Inhibitor A 3051 A-3051 A3051 KY-19382 Glycogen synthase kinase-3 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.