cns-active — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9786	Lu AF27139		P2X Receptor
	Lu AF27139 is an effective and selective antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and rat, respectively). Lu AF27139 can be used in CNS diseases st...		P2X Receptor
T11689	ITI-214	ITI214	PDE
	ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = ...		PDE
T0682	Lamivudine	GR109714X,BCH-189	HIV Protease , Reverse Transcriptase
	Lamivudine (BCH-189) is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.		HIV Protease , Reverse Transcriptase
T0688	Ganciclovir	BW 759,RS-21592,2'-Nor-2'-deoxyguanosine	Nucleoside Antimetabolite/Analog , Others , Antibiotic , Antifection , HSV
	Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegaloviru...
T22337	Ganciclovir sodium	RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium	Nucleoside Antimetabolite/Analog , Others , Antifection , HSV
	Ganciclovir sodium (Cytovene IV sodium) is the sodium salt of Ganciclovir with antiviral activity, especially against cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1).
T12899L	SEP-363856 hydrochloride	SEP-856 hydrochloride	Others , 5-HT Receptor
	SEP-363856 hydrochloride (SEP-856 hydrochloride) is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to trea...		Others , 5-HT Receptor
T5494	MW-150	MW01-18-150SRM	p38 MAPK , Autophagy
	MW-150 (MW01-18-150SRM) is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.		p38 MAPK , Autophagy
T15387	GLP-1R Antagonist 1		Glucagon Receptor
	GLP-1R Antagonist 1 is an orally active, CNS penetrant and non-competitive glucagon-like peptide 1 receptor (GLP-1R) antagonist (IC50: 650 nM).		Glucagon Receptor
T10393	AT-007		Reductase
	AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.		Reductase
T21327	Uridine triacetate	RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate	Others
	Uridine triacetate (RG 2133 triacetate) (Tri-O-acetyl uridine), an orally active prodrug of uridine, is efficiently absorbed in the gut and swiftly deacetylated in the circulation to release free uridine. It is utilized ...		Others
T61564	PF-03463275	PF-3463275	GlyT
	PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS permeability and may be used to ameliorate cognitive defici...		GlyT
T60707	Quinupramine
	Quinupramine is an orally active antidepressant that shows antidepressant activity associated with the central serotonin system, but not with the β-adrenergic system. Quinupramine is able to penetrate into the CNS and af...
TQ0291	Firategrast	SB 683699	Integrin
	Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity...		Integrin
T14835	BTRX-335140	CYM-53093	Opioid Receptor
	BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively. BTRX-335140...		Opioid Receptor
T24510	MW108	MW-108,MW01-11-108,MW 108,MW01 11 108,MW0111108
	MW108 is an active site targeted, CNS-active, p38αMAPK inhibitor.
T30234	AX-A411-BS
	AX-A411-BS is a CNS-active benzodiazepine with anxiolytic properties.
T12677	(Rac)-SEP-363856	(Rac)-SEP-856	Others
	(Rac)-SEP-363856 is the racemate of SEP-363856. SEP-363856 is an orally active and CNS active psychotropic agent with a unique		Others
T12899	SEP-363856	SEP-856	Others
	SEP-363856 is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to treatment of schizophrenia.		Others
T11056	DLK-IN-1		DNA Alkylation
	DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, retains excellent CNS permeability, and after multiple days o...		DNA Alkylation
T82425	Excitin 1
	Excitin 1, an orally active, CNS-penetrating peptide, modifies rat behavior and alters brain monoamine and amino acid levels [1].