c2c12 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9031	MCU-i4		Others , Mitochondrial Metabolism
	MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.		Others , Mitochondrial Metabolism
T1889	CP-640186	CP 640186	Acetyl-CoA Carboxylase
	CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.		Acetyl-CoA Carboxylase
T3622	CP-640186 hydrochloride	CP 640186 HCl	Acetyl-CoA Carboxylase
	CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stabilit...		Acetyl-CoA Carboxylase
T11048L	DIPQUO hydrochloride	DIPQUO hydrochloride(1269365-82-3 Free base)	Phosphorylase
	DIPQUO hydrochloride is an activator of the bone marker alkaline phosphatase (ALP), with an EC50 of 6.27 μM in C2C12 cells. DIPQUO hydrochloride promotes mouse and human osteoblast differentiation via activation of p38 M...		Phosphorylase
T35348	LDN-193189 2HCl	LDN-193189 2HCl,DM-3189 2HCl	ALK , TGF-beta/Smad
	LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.LDN-193189 2HCl inhibited ...		ALK , TGF-beta/Smad
T77697	BML-278	BML278,BML 278	Sirtuin , Histone Methyltransferase
	BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can be used to improve early embryonic development.BML-278 ind...		Sirtuin , Histone Methyltransferase
T60127	Chlorantraniliprole	Rynaxypyr,Chlorantranilipole,Rynaxpyr	Others
	Chlorantraniliprole (Rynaxypyr) is an insecticide. Chlorantraniliprole potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine re...		Others
T23351	Shz 1		Others
	induces phenotypic differentiation		Others
TP1895L1	KYL acetate(676657-00-4 free base)		Ephrin Receptor
	KYL acetate is a EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM). KYL inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM).		Ephrin Receptor
T2834	Nobiletin	Hexamethoxyflavone	Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy
	Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic...		Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy
T1935	LDN193189	LDN-193189,DM-3189,LDN 193189	ALK , TGF-beta/Smad
	LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6).		ALK , TGF-beta/Smad
T11048	DIPQUO		Others
	DIPQUO is an activator of bone marker alkaline phosphatase (ALP). DIPQUO promotes the differentiation of mouse and human osteoblasts by activating p38MAPK-β. The EC50 in C2C12 cells was 6.27 μM.		Others
T40481	IBS008738
	IBS008738, a potent TAZ activator, stabilizes TAZ, elevates the unphosphorylated TAZ level, enhances the interaction of MyoD with the myogenin promoter, upregulates gene transcription regulated by MyoD, and competes with...
T24512	MyomiR-IN-1	myomiR inhibitor-1,myomiR inhibitor 1,myomiRIN1
	myomiR-IN-1 is a myomiRs inhibitor that acts by inhibiting the translation of myoD in C2C12 cells without changing the expression level of myoD mRNA and downregulating the expression of differentiation markers.
T79546	BMP agonist 1
	BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells. It acts by inhibiting GSK3β and enhancing β-catenin signaling, ther...
T36064	N-Oleoyl Glutamine
	N-Oleoyl glutamine is an endogenous N-acyl amine.1,2It is both formed and degraded by peptidase M20 domain-containing 1 (PM20D1), a factor secreted by thermogenic adipose cells. N-Oleoyl glutamine (50 μM) induces mitocho...
T78703	PTP1B/AKR1B1-IN-2		Phosphatase
	PTP1B/AKR1B1-IN-2 (Compound 7f) is a potent inhibitor targeting both PTP1B and AKR1B1 with IC50 values of 3.2 and 2.1 μM, respectively, and K i values of 4.0 and 0.9 μM. This compound acts as an insulin mimetic and enhan...		Phosphatase
T60365	SY-LB-35
	SY-LB-35, a potent bone morphogenetic protein (BMP) receptor agonist, significantly enhances cell number and viability in the C2C12 myoblast cell line. It promotes cell cycle progression, particularly towards the S and G...
TN4997	Serpentine		IGF-1R
	Serpentine is an alkaloid found in the roots of Rosa Centifolia that acts as an insulin sensitizer to assist insulin in lowering blood glucose.Serpentine activates the phosphorylation of AMPK, which stimulates glucose up...		IGF-1R
TP1895	KYL peptide	KYL
	KYL peptide is a EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM). KYL inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM).