bak — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP1808	Bak BH3
	This peptide, generated from the BH3 domain of Bak (Flu-BakBH3), has been shown to have high-affinity binding to a surface pocket of the Bcl-XL protein that is required for its death antagonist function.
T80029	Bak BH3 (72-87), TAMRA-labeled
	Bak BH3 (72-87), TAMRA-labeled, is a bioactive peptide.
T23771	BAK2-66	BAK2 66
	BAK2-66 is a selective antagonist of the dopamine D3 receptor.
T4215	TCS-PIM-1-4a	SMI-4a	Apoptosis , Pim
	TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).		Apoptosis , Pim
T23861	CAY10526	CAY-10526,BTH,CAY 10526	Prostaglandin Receptor
	CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.		Prostaglandin Receptor
TWS1977	Kamebakaurin	Kamebakaurine	NF-κB
	1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression...		NF-κB
T3400	Bakuchiol		p38 MAPK , DNA/RNA Synthesis , Autophagy
	Bakuchiol possesses anti-tumor,and anti-helmenthic properties. It has cytotoxic activity, mainly due to its DNA polymerase1 inhibiting activity. Bakuchiol has anti-bacterial activity against oral pathogens, has great pot...		p38 MAPK , DNA/RNA Synthesis , Autophagy
T77034	Inbakicept	N-803
	Inbakicept (ALT-803) is an IL-15 superagonist complex, consisting of IL-15 mutant and IL-15Rα-Fc fusion. Inbakicept magnifies anti-CD20 mAb-mediated NK-cell responses and antibody-dependent cellular cytotoxicity (ADCC). ...
TN3486	Bakkenolide IIIa		ERK , BCL , IκB/IKK , NF-κB , Akt
	Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-ÎºB signaling.		ERK , BCL , IκB/IKK , NF-κB , Akt
TN3485	Bakkenolide III		Others
	Bakkenolide III may have cytotoxicity.		Others
TN2945	3-Hydroxybakuchiol		ATPase , Caspase
	3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, th...		ATPase , Caspase
TN3483	Bakkenolide D		IL Receptor , Histamine Receptor
	Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have obvious anti-histamine activities.		IL Receptor , Histamine Receptor
TN2562	1-Oxobakkenolide S		Others
	1-Oxobakkenolide S is a natural product for research related to life sciences. The catalog number is TN2562 and the CAS number is 18456-02-5.		Others
TN3484	Bakkenolide Db		Others
	Bakkenolide Db may have cytotoxicity.		Others
T124107	Bakuchalcone
	Bakuchalcone is a useful organic compound for research related to life sciences and the catalog number is T124107.
T2S0606	Bakkenolide A		IL Receptor , IκB/IKK , GSK-3 , TNF , Akt , Caspase , PI3K , HDAC
	Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways.
T125549	12-Hydroxyisobakuchiol
	12-Hydroxyisobakuchiol is a useful organic compound for research related to life sciences and the catalog number is T125549.
TN3482	Bakkenolide B		NOS , COX
	Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.		NOS , COX
T14846	Bz 423	BZ48	Apoptosis , BCL
	Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus...		Apoptosis , BCL
T6881	LTX-315	LTX315,Oncopore,K-K-W-W-K-K-W-Dip-K-NH2	BCL
	LTX-315 (Oncopore), the oncolytic peptide, inhibits cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.		BCL