Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 57.00 | |
5 mg | In stock | $ 139.00 | |
10 mg | In stock | $ 247.00 | |
25 mg | In stock | $ 538.00 | |
50 mg | In stock | $ 778.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 153.00 |
Description | CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway. |
Targets&IC50 | mPGES-1:1.8 μM |
In vitro | CAY10526 dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 1.8 μM without any effect on COX-2 expression[1]. |
Synonyms | CAY-10526, BTH, CAY 10526 |
Molecular Weight | 311.15 |
Formula | C12H7BrO3S |
CAS No. | 938069-71-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16 mg/mL(51.43 mM)
DMF: 16 mg/mL(51.43 mM)
Ethanol: 1 mg/ml(3.21 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CAY10526 938069-71-7 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor WM793 CAY-10526 PGE2 production Inhibitor inhibit SB2 microsomal PGE2 synthase-1 BTH A375 cleaved caspase 3 increases apoptosis increases BAX and BAK pro-apoptotic anti-apoptotic melanoma xenografts mPGES1 inhibitor PGE synthase CAY 10526 Prostaglandin E synthase inhibitor