bia — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10190	7-BIA		Phosphatase
	7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with anti-addictive properties and can be used in the study of neuropathic pain.		Phosphatase
T3354	BIA 10-2474	BIA10-2474	FAAH , Autophagy
	BIA 10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (that is, the rest o...		FAAH , Autophagy
T26797	BIA 3-335	BIA-3-335,BIA3335
	BIA 3-335, an inhibition of catechol-O-methyltransferase, could have applications for Parkinson's Disease.
T16398	Opicapone	BIA 9-1067	Transferase
	Opicapone (BIA 9-1067) reduces the ATP content of the cells (IC50: 98 μM). Opicapone is an effective third-generation catechol-O-methyltransferase inhibitor for the research of Parkinson's disease and motor fluctuations.		Transferase
T11238L	Etamicastat hydrochloride	BIA 5-453 hydrochloride	Dehydrogenase
	Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.		Dehydrogenase
T13383	Zamicastat	BIA 5-1058	BCRP , Hydroxylase , P-gp
	Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).		BCRP , Hydroxylase , P-gp
T6787	BIO-acetoxime	BIA,GSK-3 Inhibitor X	Apoptosis , GSK-3 , HSV
	BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.		Apoptosis , GSK-3 , HSV
T8649	TMBIM6 antagonist-1	BAX-inhibitor-1,BIA	mTOR
	TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor		mTOR
T3285	Eslicarbazepine Acetate	Zebinix,Aptiom,BIA 2-093,Exalief,Stedesa	Beta-Secretase , Sodium Channel
	Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled with conve...		Beta-Secretase , Sodium Channel
T3285L	Eslicarbazepine	Pazzul,EC 810-248-9,BIA 2-194,Stedesa,Erelib	Beta-Secretase , Sodium Channel
	Eslicarbazepine (Stedesa) can be used for adjunctive therapy for adults with partial-onset seizures.		Beta-Secretase , Sodium Channel
T9156	CDC25B-IN-2		Phosphatase , mTOR
	BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.		Phosphatase , mTOR
T24958	(R)-Licarbazepine Acetate	BIA2-059,Licarbazepine acetate, (R)-,BIA 2-059,BIA-2-059
	(R)-Licarbazepine Acetate is a hopeful antiepileptic drug structurally related to Carbamazepine and Oxcarbazepine.
T11238	Etamicastat	BIA 5-453	Dehydrogenase
	Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM.		Dehydrogenase
T16279	Nebicapone	BIA 3-202	Others
	Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor and is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to ...		Others
T7806	Licarbazepine	10,11-hydroxy-10,11 Dihydrocarbamezer	Others
	Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders.		Others
T4241	Rubiadin	1,3-Dihydroxy-2-Methylanthracene-9,10-Dione	Free radical scavengers , PARP , Caspase
	Rubiadin (1,3-Dihydroxy-2-Methylanthracene-9,10-Dione) possesses potent antioxidant property, it can prevent lipid peroxidation induced by FeSO4 and t-butylhydroperoxide (t-BHP) in a dose dependent manner.		Free radical scavengers , PARP , Caspase
T4946	(+)-Columbianetin acetate	COLUMBIANETIN ACETATE	Others
	(+)-Columbianetin acetate (COLUMBIANETIN ACETATE) may be helpful in regulating mast cell-mediated allergic inflammatory responses.The absorption of (+)-Columbianetin acetate is a passive diffusion process without pH-depe...		Others
T3220	Euphorbiasteroid	Euphobiasteroid,Euphorbia factor L1	Others , AMPK
	Euphorbiasteroid (Euphobiasteroid) (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.		Others , AMPK
T6411	Biapenem	CLI 86815,Biapenern,Omegacin,L 627,LJC 10627	Antibacterial , Antibiotic
	Biapenem (CLI 86815) is a 1-beta-methylcarbapenem antibiotic with a wide range of antibacterial activity. Biapenem has similar antibacterial activity to that of imipenem, but is more stable against human renal dehydropep...		Antibacterial , Antibiotic
T2S0410	Euphorbia factor L1	Euphorbiasteroid	Apoptosis , P-gp
	Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, ant...		Apoptosis , P-gp