Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-<a href="/target/Hydroxylase" style="display: inline; color: #c13a36">Hydroxylase</a> (DBH) inhibitor with an IC50 value of 107 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 14-16 weeks | $ 1,570.00 | |
50 mg | 14-16 weeks | $ 3,180.00 | |
100 mg | 14-16 weeks | $ 4,300.00 |
Description | Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM. |
Targets&IC50 | DBH:107 nM |
In vitro | Etamicastat blocks the hERG current amplitude with an IC50 value of 44 μg/mL. |
In vivo | Etamicastat (50 mg/kg;?a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats.Etamicastat (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels. |
Synonyms | BIA 5-453 |
Molecular Weight | 311.35 |
Formula | C14H15F2N3OS |
CAS No. | 760173-05-5 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Etamicastat 760173-05-5 Metabolism Dehydrogenase BIA 5-453 Inhibitor inhibitor inhibit