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Hispidin

Catalog No. T7792 CAS 555-55-5

Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties

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Hispidin, CAS 555-55-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 96.00
5 mg	In stock	$ 239.00
10 mg	In stock	$ 396.00
25 mg	In stock	$ 663.00
50 mg	In stock	$ 929.00
100 mg	In stock	$ 1,250.00
1 mL * 10 mM (in DMSO)	In stock	$ 263.00

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Purity: 99.55%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties

In vitro

Hispidin from P. linteus exhibited quenching effects against DPPH radicals, superoxide radicals, and hydrogen peroxide in a dose-dependent manner. Intracellular reactive oxygen species scavenging activity of hispidin was approximately 55% at a concentration of 30 μM. In addition, hispidin was shown to inhibit hydrogen peroxide-induced apoptosis and increased insulin secretion in hydrogen peroxide-treated cells. These combined results indicate that hispidin may act as an antidiabetic and that this property occurs through preventing β-cells from the toxic action of reactive oxygen species in diabetes[1].Hispidin inhibits protein kinase C β (PKCβ ; IC50 = 2 μM) with no activity against alkaline phosphatase[2]

Molecular Weight	246.22
Formula	C13H10O5
CAS No.	555-55-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (91.38 mM)

References and Literature

1. Jang J S , Lee J S , Lee J H , et al. Hispidin produced from Phellinus linteus protects pancreatic β-cells from damage by hydrogen peroxide[J]. Archives of Pharmacal Research, 2010, 33(6):p.853-861. 2. Gonindard C , Bergonzi C , Denier C , et al. Synthetic hispidin, a PKC inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro[J]. Cell Biology and Toxicology, 1997, 13(3):141-153.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library TGF-beta/Smad Compound Library Microbial Natural Product Library Inhibitor Library Bioactive Compound Library Epigenetics Compound Library Bioactive Compounds Library Max Ferroptosis Compound Library Human Metabolite Library Anti-Aging Compound Library

Related Products

Related compounds with same targets

Spinacine Urea Urolithin C Naringin Mucic Acid Maltose monohydrate Maltose D-Panthenol

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Keywords

Hispidin 555-55-5 Chromatin/Epigenetic Cytoskeletal Signaling Metabolism PKC Endogenous Metabolite inhibit anti-dementia anti-diabetic fungal properties Protein kinase C Inhibitor anti-oxidant anti-cancer metabolite inhibitor

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