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Gallic acid

Catalog No. T0877   CAS 149-91-7
Synonyms: 3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid

Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.

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Gallic acid Chemical Structure
Gallic acid, CAS 149-91-7
Pack Size Availability Price/USD Quantity
50 mg In stock $ 38.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.95%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
In vitro Gallic acid does not protect against H(2)O(2)-induced PC12 cell death. It reduced the viability of PC12 cells in a dose-dependent manner. Gallic acid also induces cleavage of poly (ADP-ribose) polymerase, which is strongly related to apoptosis in neurons. Gallic acid induces the phosphorylation of c-Jun N-terminal protein kinase (JNK) and the downregulation of Bcl-2 in PC12 cells. Gallic acid leads to a progressive reduction in the viability of vector-transfected PC12 cells, which is delayed in PC12 cells that overexpressed Bcl-2[2].
In vivo Gallic acid effectively protects rat erythrocytes. The antioxidant effect of the compound at the tested dosage in vivo was more prevalent than its prooxidative effects. Gallic acid has ameliorative effect on lipid peroxidation in vivo[1].
Cell Research Cell viability is measured using the MTT assay. PC12 cells are incubated at 37?C with Water2 or gallic acid at different concentrations for 24 h with or without pretreatment with resveratrol. They are then treated with the MTT solution (final concentration, 1 mg/mL) for 2 h. The dark-blue formazan crystals that formed in intact cells are dissolved in DMSO, and the absorbance at 570 nm is measured using a micro-ELISA reader.(Only for Reference)
Source
Synonyms 3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid
Molecular Weight 170.12
Formula C7H6O5
CAS No. 149-91-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 7 mg/mL (41.15 mM)

Ethanol: 32 mg/mL (188.1 mM)

DMSO: 32 mg/mL (188.1 mM)

TargetMolReferences and Literature

1. Nabavi SF, et al. Arh Hig Rada Toksikol. 2013, 64(4):553-9. 2. Kang MK, et al. Ann N Y Acad Sci. 2009, 1171:514-20. 3. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet[J]. Planta medica. 2019. 4. Lin Y, Luo T, Weng A, et al. Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling[J]. Frontiers in Immunology. 2020, 11: 3197. 5. Zhang M, Liu D, Zhang Y Q. Rapid analysis of the bioactive components in Saxifraga stolonifera, an edible and medicinal herb with anti-tumor effects, by HPLC-DAD, ESI/MSn[J]. JOURNAL OF APPLIED BOTANY AND FOOD QUALITY. 2019, 92: 123-129. 6. Dong Q, Li Y, Liu G, et al. High oxygen treatments enhance the contents of phenolic compound and ganoderic acid, antioxidant and DNA damage protective activities of Ganoderma lingzhi fruiting body[J]. Frontiers in Microbiology. 2019, 10: 2363.

TargetMolCitations

1. Chen Z, Yuan Y, Yang D, et al. Antiviral activities of Polygonum Perfoliatum L. extract and related phenolic acid constituents against hepatitis B virus. Journal of Medical Virology. 2022 2. Lin Y, Luo T, Weng A, et al. Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling. Frontiers in Immunology. 2020 Dec 7;11:580593. doi: 10.3389 3. Dong Q, Li Y, Liu G, et al. High oxygen treatments enhance the contents of phenolic compound and ganoderic acid, antioxidant and DNA damage protective activities of Ganoderma lingzhi fruiting body. Frontiers in Microbiology. 2019, 10: 2363 4. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet. Planta Medica. 2019, 85(14/15): 1128-1135 5. Zhang M, Liu D, Zhang Y Q. Rapid analysis of the bioactive components in Saxifraga stolonifera, an edible and medicinal herb with anti-tumor effects, by HPLC-DAD, ESI/MSn. JOURNAL OF APPLIED BOTANY AND FOOD QUALITY. 2019, 92: 123-129 6. Hu Q, Wang S, Cheng R, et al.Tannins in Phyllanthus emblica L. improves Cisplatin efficacy in lung cancer cells by boosting endoplasmic reticulum stress to trigger Immunogenic Cell Death.Phytomedicine.2023: 155219. 7. Zheng C, Wang Y, Bi B, et al.Gallic acid ameliorates endometrial hyperplasia through the inhibition of the PI3K/AKT pathway and the down-regulation of cyclin D1 expression.Journal of Pharmacological Sciences.2024

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Microbial Natural Product Library Anti-Cancer Approved Drug Library Tobacco Monomer Library Antiparasitic Natural Product Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Miao medicine Compound Library Anti-Aging Compound Library Lipid Metabolism Compound Library

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Keywords

Gallic acid 149-91-7 Apoptosis Immunology/Inflammation Metabolism Neuroscience NF-Κb Ferroptosis Reactive Oxygen Species COX ROS Endogenous Metabolite 3,4,5-Trihydroxybenzoic acid Gallate Inhibitor inhibit Cyclooxygenase Benzoic acid inhibitor

 

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