Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 222.00 | |
25 mg | In stock | $ 422.00 | |
50 mg | In stock | $ 635.00 | |
100 mg | In stock | $ 885.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 142.00 |
Description | Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM). |
In vitro | Boc-D-fmk inhibits TNFα-stimulated reactive oxygen species (ROS) generation [1]. Boc-D-fmk (50 μM) prevents genistein-induced apoptosis of p815 cells. The release of mitochondrial apoptotic factors is inhibited by Boc-D-fmk [2]. |
In vivo | Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after the endotoxin challenge [3]. Boc-D-FMK (single injection) results in longterm protection of MNs against root avulsion-induced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle [4]. |
Molecular Weight | 263.26 |
Formula | C11H18FNO5 |
CAS No. | 634911-80-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (474.82 mM)
You can also refer to dose conversion for different animals. More
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BOC-D-FMK 634911-80-1 Apoptosis Proteases/Proteasome Caspase BOCDFMK Inhibitor inhibit BOC D FMK inhibitor