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BD-AcAc 2

Catalog No. T10492   CAS 1208313-97-6
Synonyms: Ketone Ester

BD-AcAc 2 (Ketone Ester) is a ketone monoester and can be used as a source of oral nutritional ketones. BD-AcAc 2 can elevate plasma levels of acetoacetate and β-hydroxybutyrate, blood Na+, blood glucose levels and blood creatinine levels after oral administration in mice. BD-AcAc 2 can partly prevent muscle weakness in septic mice. BD-AcAc 2 exhibits potential to improve endurance and exercise performance in animal body. BD-AcAc 2 can also be used to research diabetes or Parkinson’s disease.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
BD-AcAc 2 Chemical Structure
BD-AcAc 2, CAS 1208313-97-6
Pack Size Availability Price/USD Quantity
5 mg In stock $ 63.00
10 mg In stock $ 88.00
50 mg In stock $ 222.00
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Purity: 99.62%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description BD-AcAc 2 (Ketone Ester) is a ketone monoester and can be used as a source of oral nutritional ketones. BD-AcAc 2 can elevate plasma levels of acetoacetate and β-hydroxybutyrate, blood Na+, blood glucose levels and blood creatinine levels after oral administration in mice. BD-AcAc 2 can partly prevent muscle weakness in septic mice. BD-AcAc 2 exhibits potential to improve endurance and exercise performance in animal body. BD-AcAc 2 can also be used to research diabetes or Parkinson’s disease.
In vivo BD-AcAc(2) would delay CNS-OT seizures in rats breathing hyperbaric oxygen (HBO(2)). Adult male rats (n = 60) were implanted with radiotelemetry units to measure electroencephalogram (EEG). One week postsurgery, rats were administered a single oral dose of BD-AcAc(2), 1,3-butanediol (BD), or water 30 min before being placed into a hyperbaric chamber and pressurized to 5 atmospheres absolute (ATA) O2 [1]. Beginning at a presymptomatic age, 2 groups of male 3xTgAD mice were fed a diet containing a physiological enantiomeric precursor of ketone bodies (KET) or an isocaloric carbohydrate diet. The results of behavioral tests performed at 4 and 7 months after diet initiation revealed that KET-fed mice exhibited significantly less anxiety in 2 different tests. 3xTgAD mice on the KET diet also exhibited significant, albeit relatively subtle, improvements in performance on learning and memory tests. Immunohistochemical analyses revealed that KET-fed mice exhibited decreased Aβ deposition in the subiculum, CA1, and CA3 regions of the hippocampus, and the amygdala [2].
Synonyms Ketone Ester
Molecular Weight 176.21
Formula C8H16O4
CAS No. 1208313-97-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 96 mg/mL (544.80 mM), sonification is recommended.

H2O: 30 mg/mL (170.25 mM), ultrasonic and heat to 60°C

TargetMolReferences and Literature

1. D'Agostino DP, et al. Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats. Am J Physiol Regul Integr Comp Physiol. 2013 May 15;304(10):R829-36. 2. Kashiwaya Y, et al. A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol Aging. 2013 Jun;34(6):1530-9.

Related compound libraries

This product is contained In the following compound libraries:
Metabolism Compound Library Immunology/Inflammation Compound Library Pyroptosis Compound Library Bioactive Compounds Library Max Bioactive Compound Library Cuproptosis Compound Library Anti-Breast Cancer Compound Library Human Metabolite Library Anti-Liver Cancer Compound Library Anti-Ovarian Cancer Compound Library

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Keywords

BD-AcAc 2 1208313-97-6 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species Ketone endurance blood glucose nutritional ketones BDAcAc 2 diabetes muscle weakness Inhibitor exercise performance Parkinson’s disease BD AcAc 2 inhibit Ketone Ester (R,R)-Ketone Ester inhibitor

 

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