Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BD-AcAc 2 (Ketone Ester) is a ketone monoester and can be used as a source of oral nutritional ketones. BD-AcAc 2 can elevate plasma levels of acetoacetate and β-hydroxybutyrate, blood Na+, blood glucose levels and blood creatinine levels after oral administration in mice. BD-AcAc 2 can partly prevent muscle weakness in septic mice. BD-AcAc 2 exhibits potential to improve endurance and exercise performance in animal body. BD-AcAc 2 can also be used to research diabetes or Parkinson’s disease.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 63.00 | |
10 mg | In stock | $ 88.00 | |
50 mg | In stock | $ 222.00 |
Description | BD-AcAc 2 (Ketone Ester) is a ketone monoester and can be used as a source of oral nutritional ketones. BD-AcAc 2 can elevate plasma levels of acetoacetate and β-hydroxybutyrate, blood Na+, blood glucose levels and blood creatinine levels after oral administration in mice. BD-AcAc 2 can partly prevent muscle weakness in septic mice. BD-AcAc 2 exhibits potential to improve endurance and exercise performance in animal body. BD-AcAc 2 can also be used to research diabetes or Parkinson’s disease. |
In vivo | BD-AcAc(2) would delay CNS-OT seizures in rats breathing hyperbaric oxygen (HBO(2)). Adult male rats (n = 60) were implanted with radiotelemetry units to measure electroencephalogram (EEG). One week postsurgery, rats were administered a single oral dose of BD-AcAc(2), 1,3-butanediol (BD), or water 30 min before being placed into a hyperbaric chamber and pressurized to 5 atmospheres absolute (ATA) O2 [1]. Beginning at a presymptomatic age, 2 groups of male 3xTgAD mice were fed a diet containing a physiological enantiomeric precursor of ketone bodies (KET) or an isocaloric carbohydrate diet. The results of behavioral tests performed at 4 and 7 months after diet initiation revealed that KET-fed mice exhibited significantly less anxiety in 2 different tests. 3xTgAD mice on the KET diet also exhibited significant, albeit relatively subtle, improvements in performance on learning and memory tests. Immunohistochemical analyses revealed that KET-fed mice exhibited decreased Aβ deposition in the subiculum, CA1, and CA3 regions of the hippocampus, and the amygdala [2]. |
Synonyms | Ketone Ester |
Molecular Weight | 176.21 |
Formula | C8H16O4 |
CAS No. | 1208313-97-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 96 mg/mL (544.80 mM), sonification is recommended.
H2O: 30 mg/mL (170.25 mM), ultrasonic and heat to 60°C
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BD-AcAc 2 1208313-97-6 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species Ketone endurance blood glucose nutritional ketones BDAcAc 2 diabetes muscle weakness Inhibitor exercise performance Parkinson’s disease BD AcAc 2 inhibit Ketone Ester (R,R)-Ketone Ester inhibitor