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3,4-Dicaffeoylquinic acid

Name: 3,4-Dicaffeoylquinic acid
Brand: TargetMol
SKU: T6S1525
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S1525Cas No. 14534-61-3

Alias Isochlorogenic acid B

3,4-Dicaffeoylquinic acid (Isochlorogenic acid B) has antioxidant activity.

3,4-Dicaffeoylquinic acid

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Purity: 98.82%

Catalog No. T6S1525Alias Isochlorogenic acid BCas No. 14534-61-3

3,4-Dicaffeoylquinic acid (Isochlorogenic acid B) has antioxidant activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$36	In Stock	In Stock
5 mg	$77	In Stock	In Stock
10 mg	$108	In Stock	In Stock
25 mg	$179	In Stock	In Stock
50 mg	$266	In Stock	In Stock
100 mg	$395	In Stock	In Stock
500 mg	$938	-	In Stock
1 mL x 10 mM (in DMSO)	$111	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.82%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

3,4-Dicaffeoylquinic acid AI Summary

3,4-Dicaffeoylquinic acid exhibits a broad spectrum of bioactivities, making it a versatile candidate for various therapeutic applications. It inhibits key enzymes involved in inflammatory pathways, such as human recombinant AKR1B1 and AKR1B10, with IC50 values of 78.0 nM and 240.0 nM, respectively. Additionally, it suppresses the formation of inflammatory mediators like 5HETE, LTB4, and 12-hydroxy-5,8,10-heptadecatrienoic acid in human polymorphonuclear leukocytes, displaying IC50 values of 749000.0 nM, 92500.0 nM, and 80000.0 nM, respectively. Notably, 3,4-Dicaffeoylquinic acid also inhibits collagenase type 5 with an IC50 of 37200.0 nM and exhibits antioxidant activity, demonstrated by scavenging DPPH radicals with an IC50 of 28900.0 nM. The compound shows promise in neuroprotection by increasing the viability of human SH-SY5Y cells exposed to hydrogen peroxide, achieving a viability increase of 75.2% at 10 µM. It has antiviral potential as well, notably against SARS-CoV-2, reducing virus-induced cytotoxicity in VERO-6 cells and inhibiting the SARS-CoV-2 3CL-Pro protease. In enzymatic assays, 3,4-Dicaffeoylquinic acid is an inhibitor of acetylcholinesterase (IC50 of 2140.0 nM) and beta-secretase 1 (IC50 of 3310.0 nM), suggesting potential for neurodegenerative disease therapeutic strategies. Its ability to inhibit melanin production via tyrosinase inhibition and impact alpha-MSH-stimulated melanogenesis further indicates its utility in dermatological contexts. Anticancer properties are evidenced by its inhibition of amyloid beta aggregation (IC50 of 4700.0 nM) and efficacy against Trypanosoma cruzi (IC50 of 286200.0 nM). It also demonstrates notable inhibition of Leishmania major DHODH with IC50 values around 630000.0 nM. While displaying broad-spectrum bioactivity, the compound's cytotoxicity against human Jurkat T cells at a very high IC50 value (>35000000.0 nM) indicates a balanced safety profile, allowing for a wide range of potential therapeutic explorations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	3,4-Dicaffeoylquinic acid (Isochlorogenic acid B) has antioxidant activity.
Synonyms	Isochlorogenic acid B

Chemical Properties

Molecular Weight	516.45
Formula	C₂₅H₂₄O₁₂
Cas No.	14534-61-3
Smiles	O[C@@H]1C[C@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1OC(=O)C=Cc1ccc(O)c(O)c1)C(O)=O
Relative Density.	1.64 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62 mg/mL (120.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9363 mL	9.6815 mL	19.3630 mL	96.8148 mL
5 mM	0.3873 mL	1.9363 mL	3.8726 mL	19.3630 mL
10 mM	0.1936 mL	0.9681 mL	1.9363 mL	9.6815 mL
20 mM	0.0968 mL	0.4841 mL	0.9681 mL	4.8407 mL
50 mM	0.0387 mL	0.1936 mL	0.3873 mL	1.9363 mL
100 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.9681 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc