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20(S)-Ginsenoside Rg3

Name: 20(S)-Ginsenoside Rg3
Brand: TargetMol
SKU: T3402
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3402Cas No. 14197-60-5

Alias S-Ginsenoside Rg3, Rg3, Ginsenoside Rg3, 20S-Ginsenoside Rg3, 20(S)-Ginsenoside-Rg3

20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial cells(HUVEC) and has anti-angiogenesis activities.

20(S)-Ginsenoside Rg3

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🥰Excellent

Purity: 99.93%

Catalog No. T3402Alias S-Ginsenoside Rg3, Rg3, Ginsenoside Rg3, 20S-Ginsenoside Rg3, 20(S)-Ginsenoside-Rg3Cas No. 14197-60-5

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$32	In Stock	In Stock
10 mg	$52	In Stock	In Stock
25 mg	$78	In Stock	In Stock
50 mg	$98	In Stock	In Stock
100 mg	$173	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.93%

Color:White

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COA LCMS HNMR

Product Introduction

20(S)-Ginsenoside Rg3 AI Summary

20(S)-Ginsenoside Rg3 exhibits a range of bioactivities across different assays and organisms. It demonstrates hydroxyl radical scavenging activity, achieving 20.0% inhibition at a concentration of 2 mM and an IC50 value of 440,000.0 nM. Significant in neurogenesis, the compound promotes differentiation and maturation of human neural stem cells; at 8 μM, it affects TUJ+MAP2+ (16.1%), GFAP+ (35.9%), and TOPRO+ cells (140.0%). It shows cytotoxicity against human cell lines, with IC50 values of 55.36 μg/mL for A549 cells and 54.0 μg/mL for HepG2 cells. Furthermore, in U251 and C6 cells, it presents inhibition rates of 99.1% and 53.07% respectively at 100 μM. 20(S)-Ginsenoside Rg3 does not significantly inhibit human DNA topoisomerase 1 and 2 or recombinant aldose reductase, with IC50 values exceeding 250,000 nM and 200,000 nM respectively. Despite this, it exhibits hepatoprotective activity in a mouse model of induced liver injury, lowering GPT levels by 63% at 30 μg/kg. The compound provides cytoprotective effects against cell death in human SH-SY5Y cells under stress from oxygen-glucose deprivation/reperfusion, enhancing viable cell percentages (69.9% to 80.4%). In addition, 20(S)-Ginsenoside Rg3 displays antiviral properties against SARS-CoV-2, inhibiting cytotoxicity in VERO-6 cells and showing some inhibition of the SARS-CoV-2 3CL-Pro protease at 20 μM and a hit score of 0.1968. It also shows moderate inhibition of Chronic Active B-Cell Receptor Signaling, GLP-1 Receptor, hepatitis C virus, and several other targets, with potencies ranging from 354.8 nM to 35,481.3 nM. Finally, it demonstrated minimal inhibition in assays targeting human HDAC6..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial cells(HUVEC) and has anti-angiogenesis activities.
Targets&IC50	Kv1.4 channel (human):32.6±2.2 μM, Na+ channel:32.2±4.5μM
Synonyms	S-Ginsenoside Rg3, Rg3, Ginsenoside Rg3, 20S-Ginsenoside Rg3, 20(S)-Ginsenoside-Rg3

Chemical Properties

Molecular Weight	785.01
Formula	C₄₂H₇₂O₁₃
Cas No.	14197-60-5
Smiles	CC(C)=CCC[C@](C)(O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@@H]3CC[C@@]21C
Relative Density.	1.3

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (127.39 mM), Sonication is recommended.

In Vivo Formulation

5% DMSO+40% PEG300+5% Tween-80+50% Saline: 2.5 mg/mL (3.18 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2739 mL	6.3693 mL	12.7387 mL	63.6935 mL
5 mM	0.2548 mL	1.2739 mL	2.5477 mL	12.7387 mL
10 mM	0.1274 mL	0.6369 mL	1.2739 mL	6.3693 mL
20 mM	0.0637 mL	0.3185 mL	0.6369 mL	3.1847 mL
50 mM	0.0255 mL	0.1274 mL	0.2548 mL	1.2739 mL
100 mM	0.0127 mL	0.0637 mL	0.1274 mL	0.6369 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc