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2,5-dimethyl Celecoxib

Catalog No. T35610   CAS 457639-26-8

2,5-dimethyl Celecoxib is a celecoxib derivative and a targeted inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), a key enzyme in the PGE2 synthesis pathway of inflammatory mediators.

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2,5-dimethyl Celecoxib Chemical Structure
2,5-dimethyl Celecoxib, CAS 457639-26-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 97.00
5 mg In stock $ 197.00
10 mg In stock $ 328.00
25 mg In stock $ 545.00
50 mg In stock $ 785.00
100 mg In stock $ 1,080.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 2,5-dimethyl Celecoxib is a celecoxib derivative and a targeted inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), a key enzyme in the PGE2 synthesis pathway of inflammatory mediators.
In vitro 2,5-dimethyl Celecoxib(1–100?μM) decreased the viability of GBM cell lines in a dose-dependent manner. 2,5-dimethyl Celecoxib downregulated β-catenin target genes expression in A-172, T98G and U-138 MG cell lines. Apoptosis was induced, and cell cycle distribution was altered after the treatment with 2,5-dimethyl Celecoxib in T98G cell line.2,5-dimethyl Celecoxib downregulated β-catenin target genes expression in patient-derived primary GBM cell lines P1 and P6[1].
In vivo 2,5-dimethyl Celecoxib prevented cardiac remodeling and markedly reduced urinary albumin excretion without altering blood pressure in mice. 2,5-dimethyl Celecoxib prevented podocyte injury, glomerulosclerosis, and interstitial fibrosis in the kidney of mice loaded with angiotensin II and high-salt load. 2,5-dimethyl Celecoxib reduced the phosphorylation level of Akt and activated glycogen synthase kinase-3, which led to the suppression of the Wnt/β-catenin signal in the heart and kidney. 2,5-dimethyl Celecoxib also reduced the expression level of snail, a key transcription factor for the epithelial–mesenchymal transition and of which gene is a target of the Wnt/β-catenin signal[2].
Molecular Weight 395.4
Formula C18H16F3N3O2S
CAS No. 457639-26-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 3 mg/mL

DMSO: 5 mg/mL

DMF: 5 mg/mL

DMSO:PBS (pH 7.2) (1:3): 0.25 mg/mL

TargetMolReferences and Literature

1. Majchrzak-Celińska A, et al. COXIBs and 2,5-dimethylcelecoxib counteract the hyperactivated Wnt/β-catenin pathway and COX-2/PGE2/EP4 signaling in glioblastoma cells. BMC Cancer. 2021 May 3;21(1):493. 2. Yamamoto M, et al. Cardiac and renal protective effects of 2,5-dimethylcelecoxib in angiotensin II and high-salt-induced hypertension model mice. J Hypertens. 2021 May 1;39(5):892-903. 3. Egashira I, et al. Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway. Cancer Sci. 2017 Jan;108(1):108-115. 4. Chen Z, et al. 2,5-dimethylcelecoxib improves immune microenvironment of hepatocellular carcinoma by promoting ubiquitination of HBx-induced PD-L1. J Immunother Cancer. 2020 Oct;8(2):e001377.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Inhibitor Library Immunology/Inflammation Compound Library Anti-Obesity Compound Library Cytoskeletal Signaling Pathway Compound Library Anti-Cancer Metabolism Compound Library GPCR Compound Library Anti-Cancer Compound Library Anti-Ovarian Cancer Compound Library Anti-Prostate Cancer Compound Library

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Keywords

2,5-dimethyl Celecoxib 457639-26-8 Apoptosis Cytoskeletal Signaling GPCR/G Protein Immunology/Inflammation Stem Cells Prostaglandin Receptor Wnt/beta-catenin 2,5dimethyl Celecoxib 2,5 dimethyl Celecoxib inhibitor inhibit

 

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