wild-type — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40379	Bax BH3 peptide (55-74), wild type	Bax BH3 peptide (55-74), wild type
	Bax BH3 peptide (55-74), wild type is a 20-amino acid peptide (Bax 1) known for its ability to induce apoptosis in various cell line models.
T9303	MRTX1133		Ras
	MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors.		Ras
T9246	JNJ-63576253		Androgen Receptor
	JNJ-63576253 is a Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).		Androgen Receptor
T1623	Lopinavir	ABT-378	SARS-CoV , HIV Protease
	Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding to serum proteins than the structurally-related dr...		SARS-CoV , HIV Protease
T8933	JNJ-63576253 free base	TRC253,JNJ-63576253	Androgen Receptor
	JNJ-63576253 free base (TRC253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the re...		Androgen Receptor
T21900	ML-336		Others
	ML-336 is an inhibitor of of the Venezuelan equine encephalitis virus (VEEV) strain TC-83.		Others
T3184	Kevetrin hydrochloride	Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride	Mdm2 , p53
	Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.		Mdm2 , p53
T2330	Rilpivirine	TMC278,R278474,DB08864	HIV Protease , Reverse Transcriptase
	Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infections.		HIV Protease , Reverse Transcriptase
T39202	CZC-54252 hydrochloride		LRRK2
	CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human...		LRRK2
T23182	PPY A		Bcr-Abl
	PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinase (IC50 of 9 and 20 nM, respectively).PPY A also inhibits the growth of Bcr-Abl T315l mutant or wild-type Bcr-Abl genetically transformed cells.		Bcr-Abl
T32108	HXJ42	HXJ-42,HXJ 42	Others
	HXJ42 is a PP1 analog that selectively and effectively acts on wild-type ZAP-70 (AS).		Others
T21946	BIMU 8		5-HT Receptor
	BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4.		5-HT Receptor
T6824	EAI045		EGFR
	EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.		EGFR
T2620	G-749	G749	Apoptosis , FLT , c-RET , TAM Receptor , Aurora Kinase
	G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants.		Apoptosis , FLT , c-RET , TAM Receptor , Aurora Kinase
T2050	PF-06447475		LRRK2
	PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.		LRRK2
T12097	Morphothiadin	GLS4	HBV
	Morphothiadin (GLS4) is a potent inhibitor on the replication of both wild-type and adefovir-resistant HBV (IC50 of 12 nM).		HBV
T5139	CZC-25146 hydrochloride		LRRK2
	CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.		LRRK2
T13273	UT-34		Androgen Receptor
	UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prost...		Androgen Receptor
T7970	7-Ethoxycoumarin		Others
	7-Ethoxycoumarin, a typical human P450 substrate, is catalyzed by both wild-type and mutant forms of CYP102A1.		Others
T4565	Tafamidis	Fx-1006A	Others
	Tafamidis (Fx-1006A) is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds to TTR with negative cooperativity (Kd1: 3 nM; Kd2: 278 nM) to stabilize the TTR di...		Others