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Morphothiadin

Catalog No. T12097   CAS 1092970-12-1
Synonyms: GLS4

Morphothiadin (GLS4) is a potent inhibitor on the replication of both wild-type and adefovir-resistant HBV (IC50 of 12 nM).

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Morphothiadin Chemical Structure
Morphothiadin, CAS 1092970-12-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 97.00
5 mg In stock $ 297.00
10 mg In stock $ 474.00
25 mg In stock $ 698.00
50 mg In stock $ 993.00
100 mg In stock $ 1,340.00
200 mg In stock $ 1,790.00
1 mL * 10 mM (in DMSO) In stock $ 329.00
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Purity: 99.61%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Morphothiadin (GLS4) is a potent inhibitor on the replication of both wild-type and adefovir-resistant HBV (IC50 of 12 nM).
Targets&IC50 HBV:12 nM
In vitro Morphothiadin is a potent inhibitor on the replication of both wild-type and adefovir-resistant HBV (IC50 of 12 nM). Morphothiadin (GLS4) shows no toxicity up to 25 μM. The cytotoxic dose whereby 50% of cells die (CC50) for primary hepatocytes is 115 μM for Morphothiadin (P<0.001). The CC90 is 190 μM for Morphothiadin (P<0.01) in HepAD38 cells. Morphothiadin strongly inhibits virus accumulation in the supernatant of HepAD38 cells at 25 nM to 100 nM (P<0.02)[2].
In vivo Virus titers have increased 83.5-fold in mice treated with 3.75 mg/kg per day of Morphothiadin, 28.3-fold among mice treated with 7.5 mg/kg per day, but only 3- to 6-fold among mice treated with the higher doses of Morphothiadin. There is generally an inverse relationship between Morphothiadin dose and virus titer, with the greatest rebound seen in mice treated with 3.75 mg/kg per day of Morphothiadin (540-fold) and the smallest rebound in mice treated with 60 mg/kg per day (23-fold) (P<0.001). The Morphothiadin doses of >7.5 mg/kg per day significantly suppresses the virus replication cycle throughout the treatment period, while Morphothiadin doses of >15 mg/kg per day suppresses virus for up to 2 weeks after the end of treatment[2].
Synonyms GLS4
Molecular Weight 509.39
Formula C21H22BrFN4O3S
CAS No. 1092970-12-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (196.31 mM), sonification is recommended.

H2O: insoluble

TargetMolReferences and Literature

1. Zhou X, et al. Effects of ketoconazole and rifampicin on the pharmacokinetics of GLS4, a novel anti-hepatitis B virus compound, in dogs. Acta Pharmacol Sin. 2013 Nov;34(11):1420-6. 2. Wu G, et al. Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly. Antimicrob Agents Chemother. 2013 Nov;57(11):5344-54.

Related compound libraries

This product is contained In the following compound libraries:
Clinical Compound Library Bioactive Compounds Library Max Anti-Viral Compound Library Drug Repurposing Compound Library Inhibitor Library Bioactive Compound Library NO PAINS Compound Library Anti-Infection Compound Library ReFRAME Related Library

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Keywords

Morphothiadin 1092970-12-1 Microbiology/Virology HBV GLS 4 GLS4 inhibit Inhibitor GLS-4 Hepatitis B virus inhibitor

 

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