senescence — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12854	SBI-797812		NAMPT
	SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM).		NAMPT
T0334	Rosiglitazone	BRL49653	Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
	Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer.		Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
T6646	Rosiglitazone hydrochloride	BRL-49653 HCl,Rosiglitazone HCl	Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
	Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.		Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
T3768	Epifriedelanol	Epifriedelinol	Others
	Epifriedelanol (Epifriedelinol) suppresses adriamycin-induced cellular senescence, replicative senescence in human fibroblasts (HDFs) and HUVECs. Because of Epifriedelanol can reduce cellular senescence in human primary ...		Others
T36010	P38 MAPK Inhibitor		p38 MAPK
	p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.		p38 MAPK
T40351	MHY-1685		mTOR
	MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.		mTOR
T71832	CTX-0124143		Histone Acetyltransferase
	CTX-0124143 is a histone acetyltransferase inhibitor with an IC50 value of 1.0 μM for KAT6A.CTX-0124143 can be used to study cellular senescence.		Histone Acetyltransferase
T1923	BRD4770		Histone Methyltransferase
	BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.		Histone Methyltransferase
T79903	Sirtuin-1 inhibitor 1		Sirtuin
	Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.		Sirtuin
T11383	GDP366		Survivin
	GDP366, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. a dual inhibitor of survivin and Op18.		Survivin
T12040	Milademetan	RAIN-32,DS-3032,DS3032b	Mdm2 , Others
	Milademetan (DS-3032) is an orally active and potent MDM2 inhibitor with antitumor activity that induces G1 cell cycle arrest, senescence, and apoptosis.Milademetan is used in the study of acute myeloid leukemia and soli...		Mdm2 , Others
T0591	D-Galactose	D-(+)-Galactose,D-Galactopyranose,Alpha-D-galactose	Endogenous Metabolite
	D-Galactose (Alpha-D-galactose) is an aldohexose that exists naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-glucose for metabolism or polysaccharide...		Endogenous Metabolite
T78393	C12FDG	5-Dodecanoylaminofluorescein di-β-D-Galactopyranoside
	C12FDG (5-Dodecanoylaminofluorescein di-beta-D-Galactopyranoside) is used as a lipophilic green fluorescent substrate for detecting beta-galactose activity, a green fluorescent substrate, is a senescence marker and is of...
TL0005	3,5-O-Dicaffeoylquinic acid	Isochlorogenic Acid A,(-)-3,5-Dicaffeoyl quinic acid,3,5-Dicaffeoylquinic Acid	Others
	3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) is an isolated compound from Artemisia argyi; its ester derivatives exert anti-leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and potential anti-giardial effects. ...		Others
T3317	SZL P1-41		Apoptosis , Others , E1/E2/E3 Enzyme
	SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediate...		Apoptosis , Others , E1/E2/E3 Enzyme
T4752	1-Aminocyclopropane-1-carboxylic acid	1-Aminocyclopropanecarboxylic acid,1-Amino-1-carboxycyclopropane,ACC	Endogenous Metabolite , NMDAR
	1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecul...		Endogenous Metabolite , NMDAR
T19320	FAPy-adenine		Others
	FAPy-adenine is an oxidized DNA base.Adenine is on the rise in the brains of people with Alzheimer's disease.Nucleoside oxidation is a biochemical marker for tumors, senescence and neurodegenerative diseases.		Others
T26872	BMVC4	BMVC 4,BMVC-4
	BMVC4 is a G-quadruplex stabilizer. BMVC4 induces senescence by activation of pathways of response to DNA damage that was independent of its telomerase inhibitory activity.
T74590	Boanmycin
	Boanmycin, an antibiotic exhibiting antitumor activity, induces cellular senescence and apoptosis [1] [2] [3].
T83432	1-DCP
	1-DCP functions as a powerful ethylene antagonist, effectively hindering ethylene's influence on fruit ripening and senescence [1].