Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Milademetan (DS-3032) is an orally active and potent MDM2 inhibitor with antitumor activity that induces G1 cell cycle arrest, senescence, and apoptosis.Milademetan is used in the study of acute myeloid leukemia and solid tumors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 178.00 | |
5 mg | In stock | $ 547.00 | |
10 mg | In stock | $ 913.00 | |
25 mg | In stock | $ 1,350.00 | |
50 mg | In stock | $ 1,820.00 | |
100 mg | In stock | $ 2,460.00 | |
500 mg | In stock | $ 4,930.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 30.00 |
Description | Milademetan (DS-3032) is an orally active and potent MDM2 inhibitor with antitumor activity that induces G1 cell cycle arrest, senescence, and apoptosis.Milademetan is used in the study of acute myeloid leukemia and solid tumors. |
In vitro |
Milademetan (DS-3032) selectively induces CDKNA1, BAX, and MDM2 expression and stabilizes TP53 in neuroblastoma cells with wild-type TP53[3]. Treatment with Milademetan (DS-3032) enhances TP53 target gene expression, leading to G1 cell cycle arrest, senescence, and apoptosis[3]. In neuroblastoma cells with wild-type TP53, independent of MYCN status, Milademetan (DS-3032, 0-2000 nM) treatment selectively inhibits viability, proliferation, and migration[2]. |
In vivo | In mice xenografted with neuroblastoma cells possessing functional TP53, oral gavage administration of Milademetan (DS-3032) at a dose of 50 mg/kg delays tumor growth and improves overall survival[2]. |
Synonyms | RAIN-32, DS-3032, DS3032b |
Molecular Weight | 618.53 |
Formula | C30H34Cl2FN5O4 |
CAS No. | 1398568-47-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (16.17 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Milademetan 1398568-47-2 Apoptosis Others Mdm2 DS 3032 RAIN-32 DS-3032 DS3032 DS3032b inhibitor inhibit