seizure — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0680	Lamotrigine	LTG,BW430C	5-HT Receptor , Sodium Channel , Autophagy
	Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity.		5-HT Receptor , Sodium Channel , Autophagy
T8963	CYM2503		Neuropeptide Y Receptor
	CYM2503 is a positive allosteric modulator (PAM) of the GAL2 receptor that potentiates galanin-induced IP1 production in vitro. It has no affinity for the orthosteric galanin binding site of the receptor (as measured by ...		Neuropeptide Y Receptor
T22746	Tesmilifene fumarate	DPPE fumarate	Histamine Receptor
	Tesmilifene fumarate (DPPE fumarate) (DPPE fumarate) is an H1C receptor antagonist。		Histamine Receptor
T3563	Lvguidingan		Others
	Lvguidingan is an Anticonvulsant agent.		Others
T11908	LY2365109 hydrochloride		GlyT
	LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.		GlyT
T0786	Clidinium bromide	Ro 2-3773	AChR
	Clidinium bromide (Ro 2-3773) , a synthetic anticholinergic agent, has been shown in experimental and clinical researchers to have a pronounced antisecretory and antispasmodic effect on the gastrointestinal tract. It can...		AChR
T0983	Penicillamine	d-penicillamin,Dimethyl Cysteine,Artamine,D-(-)-Penicillamine	Antibiotic
	Penicillamine (Artamine), possessing antineoplastic properties, induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Artamine is a beta dimethyl a...		Antibiotic
TP1187	C-Type Natriuretic Peptide (CNP) (1-22), human	CNP (1-22), human	RAAS
	C-Type Natriuretic Peptide (CNP) (1-22), human is the 1-22 fragment of C-Type Natriuretic Peptide.		RAAS
T0267	Zonisamide	AD 810,CI 912	Calcium Channel , Sodium Channel , Carbonic Anhydrase
	Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms...		Calcium Channel , Sodium Channel , Carbonic Anhydrase
T16801	(RS)-(Tetrazol-5-yl)glycine	LY 285265,D,L-(tetrazol-5-yl)glycine	NMDAR , iGluR
	(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D, and GluN1...		NMDAR , iGluR
TN2865	(E)-3,4,5-Trimethoxycinnamic acid	O-Methylsinapic acid,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid	Others
	(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) is a natural product from the roots and rhizomes of Notopterygium incisum.		Others
T10774	CFM-2		iGluR
	CFM-2, a potent and selective non-competitive antagonist of AMPAR (AMPAR), exhibits anticonvulsant activity across various seizure models.		iGluR
T2523	Rufinamide	CGP 33101,E 2080,RUF 331	Sodium Channel
	Rufinamide (E 2080), a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders.		Sodium Channel
T9299	D-Leucine	(R)-Leucine	Endogenous Metabolite
	D-Leucine ((R)-Leucine) potently terminates seizures even after the onset of seizure activity. D-leucine reduces long-term potentiation but had no effect on basal synaptic transmission in vitro.		Endogenous Metabolite
T2983	3,4,5-Trimethoxycinnamic acid	3-(3,4,5-Trimethoxyphenyl)acrylic Acid,O-Methylsinapic acid	GABA Receptor , Endogenous Metabolite
	3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.		GABA Receptor , Endogenous Metabolite
T16977	Talampanel	GYKI-53773,LY-300164	Apoptosis , GluR
	Talampanel (LY-300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models.		Apoptosis , GluR
T38808	Cyclamic acid sodium	Cyclohexylsulfamicacidsodium,Sodiumcyclamate	Carbonic Anhydrase
	Cyclamic acid sodium (Cyclohexylsulfamicacidsodium) is a carbonic anhydrase inhibitor and one of the most widely used artificial sweeteners in food and pharmaceuticals.Cyclamic acid sodium shows moderate anticonvulsant a...		Carbonic Anhydrase
T24167	Inflachromene	ICM	Others
	Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene reduces seizure severity in a mouse model of epilepsy by inhibiting HMGB1 translocation, inhibits endothelial...		Others
T2S1464	Thiocolchicoside	Thiocolchicine 2-glucoside analog,Coltramyl	Others , GABA Receptor
	Thiocolchicoside (Thiocolchicine 2-glucoside analog) (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine rece...		Others , GABA Receptor
T0939	Phenytoin	Diphenylhydantoin,5,5-Diphenylhydantoin	Virus Protease , Sodium Channel
	Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cor...		Virus Protease , Sodium Channel