receptors — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN6735	Bigelovin		Apoptosis , Reactive Oxygen Species , Retinoid Receptor , Autophagy , RAR/RXR
	Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a pote...
T7671	Myosmine		Others , AChR
	Myosmine is a minor tobacco alkaloid that is structurally related to nicotine.		Others , AChR
T12406	PEPA		iGluR
	PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.		iGluR
T3482	CFMTI		GluR
	CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist (IC50: 2.6 nM). The selectivity of CFMTI to mGluR1 is higher 2000-fold than mGluR5.		GluR
T22843	HX 531		Retinoid Receptor
	RXR antagonist		Retinoid Receptor
T14971	CIQ		NMDAR
	CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. EC50 value: 2.7 μM for NR2C and 2.8 μM for NR2D.		NMDAR
T15811	LY2955303		Others , Retinoid Receptor
	LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).		Others , Retinoid Receptor
TQ0097	AGN 193109		Retinoid Receptor , Autophagy
	AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).		Retinoid Receptor , Autophagy
T17209	UVI 3003		Retinoid Receptor , Autophagy
	UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respectively).		Retinoid Receptor , Autophagy
T3483	FTIDC		GluR
	FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibition of FTIDC for mGluR1 receptors is shown to be in noncompe...		GluR
T6598	MPEP		GluR
	MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.		GluR
T1330	Acitretin	Ro 10-1670,Etretin	Apoptosis , Retinoid Receptor , Autophagy
	Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.		Apoptosis , Retinoid Receptor , Autophagy
TN1693	Glabrone		Influenza Virus , PPAR
	Glabrone shows antiviral activity against influenza virus.		Influenza Virus , PPAR
T5341	WYC-209	WYC209	Apoptosis , Retinoid Receptor , Autophagy
	WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).		Apoptosis , Retinoid Receptor , Autophagy
T3000	Magnolol	NSC 293099,5,5'-Diallyl-2,2'-biphenyldiol	NF-κB , Retinoid Receptor , Antibacterial , PPAR , p53 , Autophagy
	Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
T3955	AR7		Retinoid Receptor
	AR7 is a retinoic acid receptor α (RARα) antagonist.		Retinoid Receptor
T1051	Retinoic acid	Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin	Retinoid Receptor , Endogenous Metabolite , PPAR , Autophagy
	Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferat...
T2497	MPEP hydrochloride		GluR
	MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).		GluR
T7370	Talarozole	R115866	Others , P450 , Retinoid Receptor , Autophagy
	Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.Talarozole for the treatment of...		Others , P450 , Retinoid Receptor , Autophagy
T7586	Trifarotene	CD5789	Retinoid Receptor , Autophagy
	Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM).		Retinoid Receptor , Autophagy