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Talarozole

Catalog No. T7370 CAS 201410-53-9

Synonyms: R115866

Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.Talarozole for the treatment of acne, psoriasis and other keratinization disorders.

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Talarozole, CAS 201410-53-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 66.00
2 mg	In stock	$ 97.00
5 mg	In stock	$ 137.00
10 mg	In stock	$ 177.00
25 mg	In stock	$ 286.00
50 mg	In stock	$ 393.00
100 mg	In stock	$ 585.00
1 mL * 10 mM (in DMSO)	In stock	$ 113.00

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Purity: 98%

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Chemical Properties

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Description	Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.Talarozole for the treatment of acne, psoriasis and other keratinization disorders.
Targets&IC50	CYP26B1/A1:0.46/5.1 nM (IC50)

Synonyms	R115866
Molecular Weight	377.51
Formula	C21H23N5S
CAS No.	201410-53-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 36 mg/mL (95.36 mM)

References and Literature

1. Elizabeth Pavez Loriè, Chamcheu J C , Vahlquist A , et al. Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis[J]. Archives of Dermatological Research, 2009, 301(7):475-485. 2. Elizabeth Pavez Loriè, Li H , Vahlquist A , et al. The involvement of cytochrome p450 (CYP) 26 in the retinoic acid metabolism of human epidermal keratinocytes[J]. Biochim Biophys Acta, 2009, 1791(3):0-228.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Metabolism Compound Library Anti-Infection Compound Library Neuronal Differentiation Compound Library Human Metabolite Library Autophagy Compound Library Orally Active Compound Library

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Keywords

Talarozole 201410-53-9 Autophagy Metabolism Others Retinoid Receptor P450 Retinoid X receptors R-115866 Retinoic acid receptors R115866 RAR/RXR inhibit Cytochrome P450 CYPs Inhibitor R 115866 inhibitor

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