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Acitretin

Catalog No. T1330 CAS 55079-83-9

Synonyms: Ro 10-1670, Etretin

Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.

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Acitretin, CAS 55079-83-9

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 111.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Purity: 99.95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.
In vitro	Acitretin stimulates ADAM10 promoter activity with an EC(50) of 1.5 mM and leads to an increase of mature ADAM10 protein that results in a two- to three-fold increase of the ratio between alpha- and beta-secretase activity in neuroblastoma cells. [1] Acitretin (5-20 μM) impairs mitochondrial phosphorylation efficiency as demonstrated by the decrease in the state 3 respiration and ATP levels, and by the increase in the lag phase of ADP phosphorylation cycle, without affecting the membrane potential. Acitretin induces Ca(2+)-mediated mitochondrial permeability transition (MPT) and decreased the adenine nucleotide translocase (ANT) content. [2] Acitretin preferentially inhibits the growth of SCL-1 cells in a dose- and time-dependent manner, but not of non-malignant keratinocyte HaCaT cells. Acitretin increases the levels of CD95 (Fas), CD95-ligand and Fas-associated death domain. Acitretin is able to induce apoptosis in skin cancer cells possibly via death receptor CD95 apoptosis pathway without affecting the viability of normal keratinocyte. [3]
In vivo	Acitretin undergoes alpha-oxidation, chain shortening O-demethylation, and glucuronidation in the perfused rat liver. [4] Acitretin rapidly appears in liver and muscle of rats, where it undergoes redistribution into skin and adipose tissue. [5]

Synonyms	Ro 10-1670, Etretin
Molecular Weight	326.43
Formula	C21H26O3
CAS No.	55079-83-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 16 mg/mL (49 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Tippmann F, et al. FASEB J, 2009, 23(6), 1643-1654. 2. Silva FS, et al. Toxicology, 2013, 306, 93-100. 3. Lin XY, et al. J Cell Mol Med, 2009, 13(9A), 2888-2898. 4. Cotler S, et al. Xenobiotica, 1992, 22(11), 1229-1237. 5. Eisenhardt EU, et al. Drug Metab Dispos, 1994, 22(1), 26-30. 6. Qiu Y, Sun Y, Xu D, et al. Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue[J]. EBioMedicine. 2018, 37: 344-355.

Citations

1. Qiu Y, Sun Y, Xu D, et al. Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue. EBioMedicine. 2018, 37: 344-355.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Metabolism Compound Library Immunology/Inflammation Compound Library Clinical Compound Library Neuronal Differentiation Compound Library Bioactive Lipid Compound Library

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Keywords

Acitretin 55079-83-9 Apoptosis Autophagy Metabolism Retinoid Receptor inhibit Retinoic acid receptors Ro 10-1670 RAR/RXR Retinoid X receptors Inhibitor Etretin inhibitor

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