psoriasis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2548	Diflorasone		Glucocorticoid Receptor
	Diflorasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorti...		Glucocorticoid Receptor
T14981	Clobetasone butyrate		Glucocorticoid Receptor
	Clobetasone butyrate, a synthetic glucocorticoid with topical anti-inflammatory activity, is effective in treating corticosteroid-responsive dermatoses, such as atopic dermatitis and psoriasis, especially within skin tis...		Glucocorticoid Receptor
T3481	Bimolane		Topoisomerase
	Bimolane is a topoisomerase II inhibitor.		Topoisomerase
T9635	Cedirogant	ABBV-157	ROR
	Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.		ROR
T16832	S18-000003		ROR
	S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production.		ROR
T17038	Tepilamide fumarate	XP-23829	Others
	Tepilamide fumarate (XP-23829) is an oral fumaric acid ester and is used in the research of moderate to severe chronic plaque psoriasis.		Others
T14369	AZD-0284		ROR
	AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].		ROR
T12399	Peldesine	BCX 34	Nucleoside Antimetabolite/Analog , HIV Protease
	Peldesine (BCX 34) is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferation with an IC50 of 800 nM. Peldesine can be used in resear...		Nucleoside Antimetabolite/Analog , HIV Protease
T4050	GSK2981278	ROR gama modulator 1	ROR
	GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).		ROR
T1561	Clobetasol propionate	Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,CCl 4725	Glucocorticoid Receptor , P450
	Clobetasol propionate (CGP9555) exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expression. This results in the synthesis of certain a...		Glucocorticoid Receptor , P450
TN1525	Convallatoxin		NF-κB , P-gp , PPAR
	Convallatoxin is a natural product		NF-κB , P-gp , PPAR
T25130	Azaribine	NSC 67239
	Azaribine, a pyrimidine analogue, is an anti-metabolite utilized in psoriasis and mycosis fungoides.
T38105	Ixekizumab	LY2439821	IL Receptor , Interleukin
	Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A with a Kd value of <3 pM.Ixekizumab blocks the binding of IL-17A to IL-17RA but not to other IL-17 ...		IL Receptor , Interleukin
T68006	Orilotimod potassium	APO805K1
	Orilotimod potassium (APO805K1) can be used to study plaque psoriasis.
T76779	Brodalumab	LP 0160,KHK-4827,AMG-827	IL Receptor
	Brodalumab (AMG 827) is a human monoclonal antibody targeting interleukin 17 receptor (IL-17R) IgG2, often used as an immunosuppressant in the treatment of psoriasis and psoriasis.		IL Receptor
T76784	Tildrakizumab	MK 3222,SCH 900222	IL Receptor
	Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody against IL-23 (p19 subunit). Tildrakizumab targets single-stranded IL-23 with a Kd value of 136 pM. Tildrakizumab can be used to study psoriasis and ps...		IL Receptor
T76778	Risankizumab	Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066	IL Receptor
	Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (Kd <10 pM) targeting the IL-23 p19 subunit. Risankizumab inhibits IL-17 production induced by human IL-23 in mouse splenocytes with an IC50 value of 2 pM.R...		IL Receptor
T13911	Tacalcitol monohydrate	Curatoderm monohydrate,TV 02 monohydrate,TV-02H monohydrate,1,24(R)-Dihydroxyvitamin D3 monohydrate	Cysteine Protease
	Tacalcitol monohydrate(Curatoderm monohydrate), a vitamin D3 analog that promotes bone development by regulating calcium ions, can be used to study psoriasis.		Cysteine Protease
T67943	RORγ inverse agonist 1
	RORγ inverse agonist 1 has anti-inflammatory activity and can be used to treat rheumatism and psoriasis.
T83624	Selenium sulfide		Antibiotic
	Selenium sulfide has antimicrobial activity and is commonly used to control dandruff, seborrheic dermatitis and psoriasis.		Antibiotic