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Clobetasol propionate

Catalog No. T1561 CAS 25122-46-7

Synonyms: Dermovate, Clobetasol 17-propionate, CGP9555, Temovate, CCl 4725

Clobetasol propionate (CGP9555) exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Clobetasol propionate Chemical Structure

Clobetasol propionate, CAS 25122-46-7

Pack Size	Availability	Price/USD
50 mg	In stock	$ 38.00
100 mg	In stock	$ 54.00
200 mg	In stock	$ 63.00
500 mg	In stock	$ 107.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 98.44%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

CYP3A5:0.206 μM (IC50), CYP3A4:15.6 μM (IC50)

Synonyms	Dermovate, Clobetasol 17-propionate, CGP9555, Temovate, CCl 4725
Molecular Weight	466.97
Formula	C25H32ClFO5
CAS No.	25122-46-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 86 mg/mL (184.2 mM)

Ethanol: 16 mg/mL (34.3 mM)

References and Literature

1. Fitzgerald P, et al. Psychol Med. 2006 Jan;36(1):37-43.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Drug Library Glutamine Metabolism Compound Library Approved Drug Library Orally Active Compound Library ReFRAME Related Library Anti-Fibrosis Compound Library Bioactive Compound Library

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Keywords

Clobetasol propionate 25122-46-7 Endocrinology/Hormones Metabolism Glucocorticoid Receptor P450 Dermovate Clobetasol 17-propionate CGP9555 Cytochrome P450 CGP 9555 Inhibitor inhibit dermatoses Clobetasol corticosteroid CYPs Temovate CGP-9555 psoriasis CCl 4725 Clobetasol Propionate inhibitor

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