Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Clobetasol propionate exerts its effect by binding to cytoplasmic <a href="/target/Glucocorticoid_Receptor" style="display: inline; color: #c13a36">Glucocorticoid Receptor</a>s and subsequently activates <a href="/target/Glucocorticoid_Receptor" style="display: inline; color: #c13a36">Glucocorticoid Receptor</a>-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. Specifically, clobetasol propionate appears to induce <a href="/target/Phospholipase" style="display: inline; color: #c13a36">Phospholipase</a> A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by <a href="/target/Phospholipase" style="display: inline; color: #c13a36">Phospholipase</a> A2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 50.00 | |
100 mg | In stock | $ 54.00 | |
200 mg | In stock | $ 63.00 | |
500 mg | In stock | $ 107.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2. |
Targets&IC50 | CYP3A5:0.206 μM (IC50), CYP3A4:15.6 μM (IC50) |
Synonyms | Temovate, Dermovate, CCl 4725, Clobetasol 17-propionate, CGP9555 |
Molecular Weight | 466.97 |
Formula | C25H32ClFO5 |
CAS No. | 25122-46-7 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: <1 mg/mL
DMSO: 86 mg/mL (184.2 mM)
Ethanol: 16 mg/mL (34.3 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Clobetasol propionate 25122-46-7 Endocrinology/Hormones Metabolism Glucocorticoid Receptor P450 Temovate Cytochrome P450 Inhibitor inhibit dermatoses corticosteroid CYPs Dermovate psoriasis CCl 4725 Clobetasol 17-propionate CGP9555 inhibitor