prolong — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2170	SKF-96365 hydrochloride	SKF96365	Apoptosis , Potassium Channel , Calcium Channel , TRP/TRPV Channel , Autophagy
	SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autopha...
T0349	Riluzole	PK 26124,RP-54274	GABA Receptor , Sodium Channel , NMDAR
	Riluzole (RP-54274) is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.		GABA Receptor , Sodium Channel , NMDAR
T5773	Moslosooflavone	5-hydroxy-7,8-dimethoxyflavone	NF-κB , Reactive Oxygen Species
	Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone significantly inhibits the transcriptional activi...		NF-κB , Reactive Oxygen Species
T3095	Tyramine	4-hydroxyphenethylamine,para-tyramine,p-Tyramine,mydrial,Tocosine,Uteramine	MAO , Endogenous Metabolite
	Tyramine (Uteramine) is an indirect sympathomimetic that occurs naturally in cheese and other foods. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems...		MAO , Endogenous Metabolite
TN5770	Gingerenone A		Nrf2
	Gingerenone A is an effective Nrf2-Gpx4 activator. It is a small molecule compound isolated from ginger. It has anti-cancer activity, can prolong the cell cycle of cancer cells, and can inhibit dextran sodium sulfate (DS...		Nrf2
T2S0843	Negletein	7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor , TNF , NOS , Interleukin
	1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces n...		IL Receptor , TNF , NOS , Interleukin
T34491	Salicylglutamic acid
	Salicylglutamic acid, as a conjugate of salicylic acid and glutamic acid, can be used to prolong the blood concentration of salicylic acid.
T26092	Risotilide
	Risotilide is a voltage-dependent potassium channel inhibitor. It can prolong cardiac action potentials and refractory periods.
T70892	K812
	K812 is an ASK1-specific inhibitor discovered to prolong survival in a mouse model of amyotrophic lateral sclerosis.
T32066	Hexafluronium Bromide	Mylaxen,Hexafluorenium bromide,Milaxen,Hexafluorenium dibromide,Esafluronio bromuro
	Hexafluronium bromide is a neuromuscular blocker and nicotinic acetylcholine receptor antagonist used in anesthesiology to prolong and enhance the skeletal muscle relaxation of succinylcholine during surgery.
T29190	YM-75466	YM 466,YM-466,YM75466,YM 75466,YM-75466 Free
	YM-75466 is a factor Xa inhibitor. YM-75466 did not prolong coagulation time even at the dose which exerted significant antithrombotic effects, while it decreased TAT level in plasma in a dose-dependent manner.
T78805	AD4		Others
	AD4, an artemisinin derivative functioning as a proteolytic targeting chimera (PROTAC) for PCLAF, effectively degrades PCLAF in RS4;11 cells with an IC50 of 0.6 nM. This degradation activates the p21/Rb axis, resulting i...		Others