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Moslosooflavone

Catalog No. T5773 CAS 3570-62-5

Synonyms: 5-hydroxy-7,8-dimethoxyflavone

Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone significantly inhibits the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages.

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Moslosooflavone, CAS 3570-62-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 84.00
5 mg	In stock	$ 196.00
10 mg	In stock	$ 295.00
25 mg	In stock	$ 497.00
50 mg	In stock	$ 723.00
100 mg	In stock	$ 987.00
500 mg	In stock	$ 1,980.00

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Purity: 98%

Biological Description

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Description	Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone significantly inhibits the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages.
In vitro	5-hydroxy-7,8-dimethoxyflavone significantly decreased TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and nitric oxide (NO) secretions from LPS/IFN-gamma stimulated RAW 264.7 cells[1].
In vivo	5-hydroxy-7,8-dimethoxyflavone can significantly prolong the survival time of hypoxic mice[2].
Animal Research	The chemical constituents, isolated and purified by column chromatography from Saussurea invo lucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice[2].
Source	Natural Products > Lamiaceae > Mosla

Synonyms	5-hydroxy-7,8-dimethoxyflavone
Molecular Weight	298.29
Formula	C17H14O5
CAS No.	3570-62-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (33.52 mM)

References and Literature

1. Chao W W , Kuo Y H , Lin B F . Anti-inflammatory Activity of New Compounds from Andrographis paniculata by NF-??B Transactivation Inhibition[J]. Journal of Agricultural and Food Chemistry, 2010, 58(4):2505-2512. 2. Jing L L , He L , Fan P C , et al. [Chemical Constituents with Anti-hypoxia Activity from Saussurea involucrata][J]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2015, 38(1):89-92.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Traditional Chinese Medicine Monomer Library Anti-Lung Cancer Compound Library NO PAINS Compound Library Selected Plant-Sourced Compound Library Traditional Mongolian Medicine Compound Library Anti-Obesity Compound Library Bioactive Compounds Library Max Anti-Breast Cancer Compound Library Anti-Parkinson's Disease Compound Library

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Keywords

Moslosooflavone 3570-62-5 Immunology/Inflammation Metabolism NF-Κb NF-κB Reactive Oxygen Species Inhibitor anti-hypoxia flavonoid anti-inflammatory inhibit 5-hydroxy-7,8-dimethoxyflavone inhibitor

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