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Tyramine

Name: Tyramine
Brand: TargetMol
SKU: T3095
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3095Cas No. 51-67-2

Alias Uteramine, Tocosine, p-Tyramine, para-tyramine, 4-hydroxyphenethylamine

Tyramine (Uteramine) is an indirect sympathomimetic that occurs naturally in cheese and other foods. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and MONOAMINE OXIDASE to prolong the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals and may be a neurotransmitter in some invertebrate nervous systems.

Tyramine

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Purity: 99.92%

Catalog No. T3095Alias Uteramine, Tocosine, p-Tyramine, para-tyramine, 4-hydroxyphenethylamineCas No. 51-67-2

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$42	In Stock	In Stock
1 g	$50	-	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.92%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Tyramine AI Summary

Tyramine exhibits a diverse range of bioactivities across multiple assays and targets. It shows high potency in opioid receptor assays, with extremely low IC50 values in both guinea pig ileum and rat brain assays, indicating potential strong opioid agonist activity. The compound also demonstrates high potency in displacing specifically bound [3H]naloxone, suggesting potent opioid receptor binding. In addition to opioid receptors, Tyramine interacts with Dopamine receptors D1 and D2, though with relatively low affinity (Ki values of 390,000 nM and 160,000 nM, respectively), and exhibits low potency in displacing [3H]spiperone from human D2 and D4 receptors. It also shows binding affinity to other receptors such as 5-hydroxytryptamine (serotonin), with a Kd value of 8511.38 nM. Tyramine is evaluated as a substrate for Dopamine beta-hydroxylase (DBH) from bovine adrenals, with a Km value of 2000000 nM and a Kcat value of 85 s-1, and exhibits affinity towards Phenylethanolamine N-Methyltransferase (PNMT) with a Ki value of 294000 nM. Notably, Tyramine has antiplasmodial activity against chloroquine-resistant Plasmodium falciparum, with an IC50 value of 160,000 nM, and exhibits antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in VERO-6 cells at an IC50 greater than 20,000 nM. It also inhibits the SARS-CoV-2 3CL-Pro protease with an inhibition percentage of 7.67% at 20µM concentration. Further, Tyramine shows inhibitory effects on enzyme targets such as mushroom tyrosinase, Monoamine Oxidase (MAO-A and MAO-B), and Dopamine beta-monooxygenase. The compound demonstrates weak to moderate binding to Beta adrenergic receptors and significant inhibitory activity in assays for L-tryptophan and TEA uptake. Lastly, Tyramine exhibits agonistic activity at the TAAR1 receptor across human, rat, and mouse models, with varying EC50 values (76 nM, 30 nM, and 280 nM respectively), and an Emax indicating potent receptor activity. It does not induce drug-induced liver injury and shows broad inhibitory effects including antiprotozoal activity against Giardia lamblia and Entamoeba histolytica..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tyramine (Uteramine) is an indirect sympathomimetic that occurs naturally in cheese and other foods. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and MONOAMINE OXIDASE to prolong the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals and may be a neurotransmitter in some invertebrate nervous systems.
Targets&IC50	TAAR1 (human):34 nM(Ki)
Synonyms	Uteramine, Tocosine, p-Tyramine, para-tyramine, 4-hydroxyphenethylamine

Chemical Properties

Molecular Weight	137.18
Formula	C₈H₁₁NO
Cas No.	51-67-2
Smiles	NCCc1ccc(O)cc1
Relative Density.	1.103g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (455.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (14.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.2897 mL	36.4485 mL	72.8969 mL	364.4846 mL
5 mM	1.4579 mL	7.2897 mL	14.5794 mL	72.8969 mL
10 mM	0.7290 mL	3.6448 mL	7.2897 mL	36.4485 mL
20 mM	0.3645 mL	1.8224 mL	3.6448 mL	18.2242 mL
50 mM	0.1458 mL	0.7290 mL	1.4579 mL	7.2897 mL
100 mM	0.0729 mL	0.3645 mL	0.7290 mL	3.6448 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc