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Search Results for " prodrug "

20

Compounds

Cat No. Product Name Synonyms Targets
T64414 PRI-724 C-82 prodrug,Foscenvivint Wnt/beta-catenin
PRI-724 (C-82 prodrug) is a selective small-molecule inhibitor of β-catenin/CBP interaction.
T72406 Tofacitinib Prodrug-1
Tofacitinib Prodrug-1 is an effective and oral active prodrug to mitigate the systemic adverse effects of Tofacitinib. Tofacitinib Prodrug-1 can effectively attenuate the oxazolone-induced colitis in mice model with low ...
T64076 Spermine Prodrug-1
Spermine Prodrug-1 is a redox-sensitive spermine prodrug. Spermine Prodrug-1 inhibits wild-type (CMS-24949) and spermine synthase gene (SMS) mutant (CMS-26559, and CMS-6233) fibroblasts with IC50 values of 326.7. 198.5, ...
T3934 Isavuconazonium sulfate Antifungal
Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), wh...
T33281 Melflufen Prodrug J-1, Melflufen, Melphalan flufenamide,Melphalan flufenamide,J 1,J1,J-1
Melphalen fluoroaniline, also known as melphalen, J-1, or prodrug J-1, is a prodrug of melphalen, in which the alkylating agent melphalen is combined with fluoroaniline and has potential antitumor and antiangiogenic acti...
T0103 Dipivefrin hydrochloride Dipivefrin HCL Adrenergic Receptor , AChR
Dipivefrin hydrochloride (Dipivefrin HCl) that is available as an ophthalmic solution is a prodrug of adrenaline, which is used to treat glaucoma.
T15102 Dexamethasone palmitate DXP Glucocorticoid Receptor
Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone, shows a 47-fold lower affinity for the glucocorticoid receptor than Dexamethasone. Dexamethasone palmitate is a glucocorticoid receptor agonist and an...
T19438 Myristyl nicotinate Tetradecyl nicotinate GPR
Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug being developed for delivery of nicotinic acid (NIC) into the skin for prevention of actinic keratosis and its progression to skin cancer.
T1579 Mestranol Devocin,Norquen,Menophase Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Mestranol (Devocin), a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.
T0389 Dabigatran etexilate BIBR 1048 Thrombin
Dabigatran etexilate (BIBR 1048) is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation.
T7840 2',3',5'-triacetyl-5-Azacytidine Nsc291930 DNA Methyltransferase , Others
2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.
TC0025 Testosterone acetate NSC523836,NSC-523836,NSC 523836 Others
Testosterone acetate (NSC-523836) is a hormone with in vitro antitumor activity.
T13278 Valecobulin hydrochloride CKD-516 hydrochloride Microtubule Associated
Valecobulin hydrochloride (CKD-516 hydrochloride) is a potent inhibitor of β-tubulin polymerization. Valecobulin hydrochloride is a valine prodrug and a vascular disrupting agent.
TQ0095 Brincidofovir CMX001,HDP-CDV Others , Antiviral , HSV
Brincidofovir (HDP-CDV) is an orally active, lipophilic form of cidofovir. It has enhanced activity compared to CDV against certain adenoviruses, herpesviruses, and orthopoxviruses.
T40475 Ceftobiprole medocaril BAL5788 Antibacterial
Ceftobiprole medocaril (BAL5788) is the parenteral prodrug of Ceftobiprole. Ceftobiprole is a broad-spectrum cephalosporin with activity against Methicillin-resistant staphylococcus aureus (MRSA).
T4190 Ticlopidine PCR 5332,Ticlid ATPase , Adiponectin receptor
Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.
T1675 Adefovir dipivoxil Hepsera,GS 0840,Preveon Others , HBV , Reverse Transcriptase
Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficienc...
T5133 Dabigatran Etexilate Mesylate BIBR 1048MS,Dabigatran etexilate methanesulfonate Thrombin
Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI, Ki: 4.5 nM).
T8160 EGCG Octaacetate Others , Antibacterial
EGCG Octaacetate, a prodrug of EGCG, is utilized to enhance the stability and bioavailability of EGCG in vivo. It has high efficacy, bioavailability, anti-oxidation, and anti-angiogenesis capacities.
T7387 Ceftaroline fosamil TAK-599,PPI0903 Antibacterial , Antibiotic
Ceftaroline fosamil (TAK-599) is a cephalosporin, with activity against Gram-positive pathogens.

Compounds

PRI-724
T64414
Synonym: C-82 prodrug,Foscenvivint
Target: Wnt/beta-catenin
Tofacitinib Prodrug-1
T72406
Synonym:
Target:
Spermine Prodrug-1
T64076
Synonym:
Target:
Isavuconazonium sulfate
T3934
Synonym:
Target: Antifungal
Melflufen
T33281
Synonym: Prodrug J-1, Melflufen, Melphalan flufenamide,Melphalan flufenamide,J 1,J1,J-1
Target:
Dipivefrin hydrochloride
T0103
Synonym: Dipivefrin HCL
Target: Adrenergic Receptor, AChR
Dexamethasone palmitate
T15102
Synonym: DXP
Target: Glucocorticoid Receptor
Myristyl nicotinate
T19438
Synonym: Tetradecyl nicotinate
Target: GPR
Mestranol
T1579
Synonym: Devocin,Norquen,Menophase
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Dabigatran etexilate
T0389
Synonym: BIBR 1048
Target: Thrombin
2',3',5'-triacetyl-5-Azacytidine
T7840
Synonym: Nsc291930
Target: DNA Methyltransferase, Others
Testosterone acetate
TC0025
Synonym: NSC523836,NSC-523836,NSC 523836
Target: Others
Valecobulin hydrochloride
T13278
Synonym: CKD-516 hydrochloride
Target: Microtubule Associated
Brincidofovir
TQ0095
Synonym: CMX001,HDP-CDV
Target: Others, Antiviral, HSV
Ceftobiprole medocaril
T40475
Synonym: BAL5788
Target: Antibacterial
Ticlopidine
T4190
Synonym: PCR 5332,Ticlid
Target: ATPase, Adiponectin receptor
Adefovir dipivoxil
T1675
Synonym: Hepsera,GS 0840,Preveon
Target: Others, HBV, Reverse Transcriptase
Dabigatran Etexilate Mesylate
T5133
Synonym: BIBR 1048MS,Dabigatran etexilate methanesulfonate
Target: Thrombin
EGCG Octaacetate
T8160
Synonym:
Target: Others, Antibacterial
Ceftaroline fosamil
T7387
Synonym: TAK-599,PPI0903
Target: Antibacterial, Antibiotic
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TargetMol