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Isavuconazonium sulfate

Catalog No. T3934 CAS 946075-13-4

Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), which catalyzes the demethylation of lanosterol to yield ergosterol, an important component of the fungal cell membrane. Isavuconazonium Sulfate is a prodrug of the triazole antifungal agent isavuconazole, with broad-spectrum antifungal activity. Inhibition of CYP51 leads to a decrease in fungal ergosterol production and disrupts the synthesis of the fungal cell membrane, which decreases membrane integrity, increases cell membrane permeability and promotes the loss of essential intracellular elements. This results in fungal cell lysis and death.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Isavuconazonium sulfate Chemical Structure

Isavuconazonium sulfate, CAS 946075-13-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 68.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 197.00
50 mg	In stock	$ 297.00
100 mg	In stock	$ 428.00
500 mg	In stock	$ 969.00

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Purity: 99.42%

Purity: 97%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	814.84
Formula	C35H36F2N8O9S2
CAS No.	946075-13-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

H2O: Insoluble

References and Literature

1. Kovanda LL, et al. Pharmacodynamics of Isavuconazole for Invasive Mold Disease: Role of Galactomannan for Real-Time Monitoring of Therapeutic Response. Clin Infect Dis. 2017 May 2.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Fluorochemical Library FDA-Approved & Pharmacopeia Drug Library Orally Active Compound Library Drug-induced Liver Injury (DILI) Compound Library Bioactive Compound Library Immunology/Inflammation Compound Library Clinical Compound Library NO PAINS Compound Library Approved Drug Library

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Related compounds with same targets

Fenhexamid Torachrysone tetraglucoside Flusilazole Fluazinam (+)-Columbianetin Chlorothalonil Carvacrol 5-Bromo-5-nitro-1,3-dioxane

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Keywords

Isavuconazonium sulfate 946075-13-4 Microbiology/Virology Antifungal inhibit antifungal prodrug aspergillosis BAL8557-002 Fungal mucormycosis invasive Isavuconazonium Isavuconazonium Sulfate Inhibitor infections inhibitor

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