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Ceftaroline fosamil

Catalog No. T7387 CAS 400827-46-5

Synonyms: TAK-599, PPI0903

Ceftaroline fosamil (TAK-599) is a cephalosporin, with activity against Gram-positive pathogens.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ceftaroline fosamil, CAS 400827-46-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 54.00
5 mg	In stock	$ 128.00
10 mg	In stock	$ 213.00
25 mg	In stock	$ 397.00
50 mg	In stock	$ 622.00
100 mg	In stock	$ 885.00
1 mL * 10 mM (in DMSO)	In stock	$ 215.00

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Purity: 98.94%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ceftaroline fosamil (TAK-599) is a cephalosporin, with activity against Gram-positive pathogens.
In vivo	Ceftaroline fosamil 600 mg given every 12 h was superior to ceftriaxone 2 g given every 24 h for the treatment of Asian patients with PORT III-IV community-acquired pneumonia. These data suggest that ceftaroline fosamil should be regarded as an alternative to ceftriaxone in empirical treatment regimens for this patient population.

Synonyms	TAK-599, PPI0903
Molecular Weight	744.74
Formula	C24H25N8O10PS4
CAS No.	400827-46-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 14 mg/mL (32.22 mM), Sonification and heating are recommended.

References and Literature

1. Zhong, Nan Shan, Sun, Tieying, Zhuo, Chao,et,al. Ceftaroline fosamil versus ceftriaxone for the treatment of Asian patients with community-acquired pneumonia: a randomised, controlled, double-blind, phase 3, non-inferiority with nested superiority trial[J]. Lancet Infectious Diseases, 2015, 15(2):161-171. 2. So W, et al. Comparison of in vivo and in vitro pharmacodynamics of a humanized regimen of 600 milligrams of Ceftaroline Fosamil every 12 hours against Staphylococcus aureus at initial inocula of 106 and 108 CFU per milliliter. Antimicrob Agents Chemother. 2014 Nov;58(11):6931-3.

Related compound libraries

This product is contained In the following compound libraries：

EMA Approved Drug Library Drug Repurposing Compound Library Anti-Bacterial Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max Approved Drug Library Anti-Infection Compound Library Beta-Lactam Compound Library Pediatric Drug Library FDA-Approved & Pharmacopeia Drug Library

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Related compounds with same targets

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ceftaroline fosamil 400827-46-5 Microbiology/Virology Antibiotic Antibacterial N-phosphono inhibit MRSA TAK-599 TAK599 PPI-0903 TAK 599 PPI 0903 T-91825 Bacterial Inhibitor infection PPI0903 prodrug inhibitor

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