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Ceftaroline fosamil

Catalog No. T7387   CAS 400827-46-5
Synonyms: TAK-599, PPI0903

Ceftaroline fosamil (TAK-599) is a cephalosporin, with activity against Gram-positive pathogens.

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Ceftaroline fosamil Chemical Structure
Ceftaroline fosamil, CAS 400827-46-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 54.00
5 mg In stock $ 128.00
10 mg In stock $ 213.00
25 mg In stock $ 397.00
50 mg In stock $ 622.00
100 mg In stock $ 885.00
1 mL * 10 mM (in DMSO) In stock $ 215.00
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Purity: 98.94%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ceftaroline fosamil (TAK-599) is a cephalosporin, with activity against Gram-positive pathogens.
In vivo Ceftaroline fosamil 600 mg given every 12 h was superior to ceftriaxone 2 g given every 24 h for the treatment of Asian patients with PORT III-IV community-acquired pneumonia. These data suggest that ceftaroline fosamil should be regarded as an alternative to ceftriaxone in empirical treatment regimens for this patient population.
Synonyms TAK-599, PPI0903
Molecular Weight 744.74
Formula C24H25N8O10PS4
CAS No. 400827-46-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 14 mg/mL (32.22 mM), Sonification and heating are recommended.

TargetMolReferences and Literature

1. Zhong, Nan Shan, Sun, Tieying, Zhuo, Chao,et,al. Ceftaroline fosamil versus ceftriaxone for the treatment of Asian patients with community-acquired pneumonia: a randomised, controlled, double-blind, phase 3, non-inferiority with nested superiority trial[J]. Lancet Infectious Diseases, 2015, 15(2):161-171. 2. So W, et al. Comparison of in vivo and in vitro pharmacodynamics of a humanized regimen of 600 milligrams of Ceftaroline Fosamil every 12 hours against Staphylococcus aureus at initial inocula of 106 and 108 CFU per milliliter. Antimicrob Agents Chemother. 2014 Nov;58(11):6931-3.

Related compound libraries

This product is contained In the following compound libraries:
EMA Approved Drug Library Drug Repurposing Compound Library Anti-Bacterial Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max Approved Drug Library Anti-Infection Compound Library Beta-Lactam Compound Library Pediatric Drug Library FDA-Approved & Pharmacopeia Drug Library

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Keywords

Ceftaroline fosamil 400827-46-5 Microbiology/Virology Antibiotic Antibacterial N-phosphono inhibit MRSA TAK-599 TAK599 PPI-0903 TAK 599 PPI 0903 T-91825 Bacterial Inhibitor infection PPI0903 prodrug inhibitor

 

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