polarization — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T23146	PHA 568487 free base	PHA 568487	AChR
	The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia...		AChR
T37591	IMP-1710		DUB
	IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.		DUB
T11765	KPLH1130		Dehydrogenase , PDK
	KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macrophage polarization and mitigates proinflammatory reactions.		Dehydrogenase , PDK
TN1786	Isomerazin	Isomeranzin	ERK , NF-κB , AChE
	Isomerazin (Isomeranzin) has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.		ERK , NF-κB , AChE
T20763	Betamethasone disodium phosphate	Vista-Methasone,NSC90616,Betamethasone 21-phosphate disodium salt,NSC-90616	Others
	Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) is a corticosteroid with anti-inflammatory activity that promotes the polarization of M1 to M2 macrophages by decreasing the secretion of pro-in...		Others
T19397	L-Methionine sulfoxide	H-Met(O)-OH	Endogenous Metabolite
	L-Methionine sulfoxide (H-Met(O)-OH) (H-Met(O)-OH) is a metabolite of Methionine. (H-Met(O)-OH) modulates oxidative stress and purinergic signaling parameters, and induces M1/classical macrophage polarization.		Endogenous Metabolite
T4953	Neotuberostemonine		NOS
	Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM)-induced pulmonary fibrosis through suppressing the recruit...		NOS
T21618L	Myelin Basic Protein (87-99) Acetate	Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base)	Others
	Myelin Basic Protein (87-99) Acetate (Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base)) is an encephalitogenic peptide that induces basic protein-specific T cell proliferation. Myelin Basic Protein (87-99) Ac...		Others
T16478	PF-04447943	PF 04447943,Edelinontrine,PF04447943	PDE
	PF-04447943 (Edelinontrine) is a potent and selective phosphodiesterase 9A inhibitor with an IC50 of 12 nM, which is 78-fold more selective than that used for other PDE family members (IC50>1000 nM).PF-04447943 exhibits ...		PDE
T4535L	Etomoxir	(R)-(+)-Etomoxir	Antioxidant , CPT
	Etomoxir is a carnitine palmitoyltransferase 1a (CPT-1a) inhibitor that inhibits fatty acid oxidation by inhibiting CPT-1a and inhibits palmitate oxidation in humans, rats, and guinea pigs. Etomoxir has an inhibitory eff...		Antioxidant , CPT
T2S0837	Astragalus Polysacharin	2-(Chloromethyl)-4-(4-nitrophenyl)thiazole,89250-26-0	TAM Receptor
	2-(Chloromethyl)-4-(4-nitrophenyl)thiazole is a natural product derived from Astragalus propinquus.2-(Chloromethyl)-4-(4-nitrophenyl)thiazole exhibits anticancer activity. 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole posse...		TAM Receptor
T70367	SNU-BP
	SNU-BP is an agonist of PPAR-gamma, inhibiting lipopolysaccharide (LPS)-induced NO production and pro-inflammatory cytokines. SNU-BP potentiates interleukin-4-induced arginase-1 expression, and promotes microglial polari...
T79590	Anti-neuroinflammation agent 1		NOD-like Receptor (NLR)
	Anti-neuroinflammation Agent 1 effectively modulates BV2 microglia cell polarization, shifting from an M1 to an M2 phenotype [1].		NOD-like Receptor (NLR)
T72430	L-Kynurenine sulfate
	L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist, activates AHR-driven polarization of naive T cells towards the anti-inflammatory Treg phenotype.
T41173	FAM-DEALAHypYIPMDDDFQLRSF
	FAM-DEALAHypYIPMDDDFQLRSF is a 5,6-carboxyfluorescein (FAM) labeled HIF-1α peptide. It binds with high affinity to von Hippel-Lindau (VHL) protein (KD= 3 nM). Can be used to assess ligand binding to VHL in a direct fluor...
T41172	FAM-DEALA-Hyp-YIPD
	FAM-DEALA-Hyp-YIPD is a fluorescent HIF-1α peptide (Kd= 180-560 nM). Can be used to assess VHL binding in Fluorescence Polarization (FP) displacement assay, and evaluate the effect of VHL binding on degradation activity....
T74013	Geldanamycin-FITC
	Geldanamycin-FITC, a fluorescent probe derived from Geldanamycin, is applicable in fluorescence polarization assays to identify HSP90 inhibitors and can be employed to detect cell surface HSP90 [1] [2] [3]. It requires p...
T82905	BDP TR azide
	BDP TR azide, a click chemistry reagent featuring an azide group, readily undergoes reactions with alkynes, DBCO, and BCN. Additionally, this compound functions as a fluorescent dye suitable for applications in fluoresce...
T78370	Myelin Basic Protein(87-99) TFA
	Myelin Basic Protein(87-99) TFA, an encephalitogenic peptide, promotes basic protein-specific T cell proliferation and induces Th1 polarization in peripheral blood mononuclear cells, which is associated with the pathogen...
T78697	Keap1-Nrf2-IN-15
	Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescence polarization (FP) assay and 2.5 nM in a time-resolved fluorescence re...