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Astragalus Polysacharin

Catalog No. T2S0837

Synonyms: 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole, 89250-26-0

2-(Chloromethyl)-4-(4-nitrophenyl)thiazole is a natural product derived from Astragalus propinquus.2-(Chloromethyl)-4-(4-nitrophenyl)thiazole exhibits anticancer activity. 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole possesses anticancer activity and has been shown to be active in hepatocellular carcinoma (HCC) by inhibiting the M2 polarization of tumor-associated macrophages (TAM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Astragalus Polysacharin Chemical Structure

Astragalus Polysacharin, CAS N/A

Pack Size	Availability	Price/USD
10 mg	In stock	$ 42.00
25 mg	In stock	$ 62.00
50 mg	In stock	$ 85.00
100 mg	In stock	$ 123.00
500 mg	Inquiry	$ 324.00

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Purity: 70%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	2-(Chloromethyl)-4-(4-nitrophenyl)thiazole is a natural product derived from Astragalus propinquus.2-(Chloromethyl)-4-(4-nitrophenyl)thiazole exhibits anticancer activity. 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole possesses anticancer activity and has been shown to be active in hepatocellular carcinoma (HCC) by inhibiting the M2 polarization of tumor-associated macrophages (TAM).
In vitro	Astragalus polysacharin (APS) (100 μg/mL; PBMCs) induced mature DCs could stimulate the proliferation of allogeneic T lymphocytes. The proliferation index of T cells increased with an increased ratio of stimulator cells to effector cells (P < 0.05). Levels of IL-12 and IFN-gamma in the co-culture supernatant significantly increased in a time-dependent manner (P < 0.05). APS could in vitro induce DCs to mature, promote its antigen-presenting capacity, effectively activate CTLs, and enhance the anti-tumor function of the organism.[2]
In vivo	Astragalus polysacharin (APS) (20 mg/kg; intragastric; once daily; 10 weeks; diabetes-induced SD rats) administration decreased the rats' fasting plasma glucose (FPG) levels and body weight. APS (20 mg/kg) administration improved the cognitive performance of diabetes-induced rats in the Morris water maze test. APS (20 mg/kg) administration reduced the number of dead cells in the CA1 region of the hippocampus. Furthermore, APS (20 mg/kg) administration obviously upregulated the phosphorylation levels CREB, NMDA, and CaMK II. CONCLUSIONS These results suggest that APS has neuroprotective effects, and it may be a candidate for the treatment of neurodegenerative diseases such as diabetic cognitive impairment.[1]

Synonyms	2-(Chloromethyl)-4-(4-nitrophenyl)thiazole, 89250-26-0
Molecular Weight	N/A

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 31.25 mg/mL, Sonication is recommended.

DMSO: 50 mg/mL (196.32 mM)

References and Literature

1. Li C, et al. Astragalus polysacharin inhibits hepatocellular carcinoma-like phenotypes in a murine HCC model through repression of M2 polarization of tumour-associated macrophages. Pharm Biol. 2021;59(1):1533-1539. 2. Zhang G, et al. Neuroprotective Effect of Astragalus Polysacharin on Streptozotocin (STZ)-Induced Diabetic Rats. Med Sci Monit. 2019;25:135-141. 3. Jing XN, et al. In vitro anti-tumor effect of human dendritic cells vaccine induced by astragalus polysacharin: an experimental study. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014;34(9):1103-1107.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Membrane Protein-targeted Compound Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max Bioactive Compound Library Selected Plant-Sourced Compound Library

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Keywords

Astragalus Polysacharin Tyrosine Kinase/Adaptors TAM Receptor 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole 89250-26-0 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.