plasma — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40312	Plasma kallikrein-IN-1
	Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.
T61403	Plasma kallikrein-IN-3
	Plasma kallikrein-IN-3, a potent inhibitor ( IC 50 : 0.15 μM) of plasma kallikrein, finds application in research related to hereditary angioedema, diabetic macular edema, and diabetic retinopathy [1].
T72337	Plasma kallikrein-IN-2
	Plasma kallikrein-IN-2, a potent inhibitor of plasma kallikrein (PKal) with an inhibitory concentration (IC) 50 value of 0.1 nM, is utilized in research targeting hereditary angioedema, diabetic macular edema, and diabet...
T16369	O-Desmethyl gefitinib		EGFR
	O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 acti...		EGFR
T9215	ELOVL6-IN-2		Others
	ELOVL6-IN-2 is a orally active and selective ELOVL6 inhibitor.		Others
T26019	R59949	R-59949,R 59949	Others , PKC
	R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.		Others , PKC
T34532	Sari 59-801	Sari-59-801	Others
	Sari 59-801 is a novel, orally effective hypoglycemic compound.		Others
T14984	CLP257		Potassium Channel
	CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it al...		Potassium Channel
T8235	L-732138		Neurokinin receptor
	L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)		Neurokinin receptor
T11793	KY-05009		Wnt/beta-catenin
	KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity o...		Wnt/beta-catenin
T1736	Apixaban	BMS-562247-01	Factor Xa
	Apixaban (BMS-562247-01) is an orally active inhibitor of coagulation factor Xa with anticoagulant activity. Apixaban directly inhibits factor Xa, thereby interfering with the conversion of prothrombin to thrombin and pr...		Factor Xa
TP1158	Copper tripeptide	GHK-Cu	Others , Endogenous Metabolite
	Copper tripeptide (GHK-Cu) is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine. The tripeptide has strong affinity for copper(II) and was first isolated from human plasma. It can be found...		Others , Endogenous Metabolite
T16075	(Rac)-Idroxioleic acid	2-Hydroxyoleic acid,2-OHOA,Minerval	Apoptosis
	(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a fatty acid amide hydrolase inhibitor with anti-tumor effect. It binds to the plasma membrane and alters lipid organization.		Apoptosis
T12146	N-Desmethyl-Apalutamide	N-Desmethyl Apalutamide	P450 , Androgen Receptor
	N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.		P450 , Androgen Receptor
T2499	Torcetrapib	CP-529414	CETP
	Torcetrapib (CP-529414) is a cholesteryl ester transfer protein (CETP) inhibitor that reduces the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. Torcetrapib failed in phase III trials due to exces...		CETP
T10353	APX-115 free base	Ewha-18278 free base	NADPH-oxidase , NADPH
	APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kid...		NADPH-oxidase , NADPH
T12372	PAT-505		EGFR
	PAT-505 is an orally available, selective and potent inhibitor of autologous epidermal growth factor (IC50 2 nM in Hep3B cells, 9.7 nM in human blood, 62 nM in mouse plasma).		EGFR
TP2124L	Somatostatin 1-28 acetate	Somatostatin 1-28 acetate(74315-46-1 Free base)	Somatostatin
	Somatostatin 1-28 acetate circulates in human plasma. Approximately 46% of the total somatostatin-like immunoreactivity in plasma is due to Somatostatin 1-28 acetate.		Somatostatin
T60104	Mycophenolic acid-β-D-glucuronide solution		Others
	Mycophenolic acid glucuronide is the glucuronide metabolite of mycophenolic acid in human plasma.		Others
T6999	Teneligliptin hydrobromide	Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide)	Others , Proteasome , DPP-4
	Teneligliptin hydrobromide (MP-513 (hydrobromide)) is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 ...		Others , Proteasome , DPP-4