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PAT-505

Catalog No. T12372 CAS 1782070-22-7

PAT-505 is an orally available, selective and potent inhibitor of autologous epidermal growth factor (IC50 2 nM in Hep3B cells, 9.7 nM in human blood, 62 nM in mouse plasma).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PAT-505, CAS 1782070-22-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 523.00
25 mg	8-10 weeks	$ 1,820.00
50 mg	8-10 weeks	$ 2,380.00
100 mg	8-10 weeks	$ 3,100.00

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Purity: 98.84%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PAT-505 is an orally available, selective and potent inhibitor of autologous epidermal growth factor (IC50 2 nM in Hep3B cells, 9.7 nM in human blood, 62 nM in mouse plasma).
Targets&IC50	Autotaxin (human blood ):9.7 nM, Autotaxin (Hep3B cells):2 nM, Autotaxin (mouse plasma):62 nM
In vivo	PAT-505 is an effective, selective, and non-competitive inhibitor, exhibiting significant inhibition of ATX activity in plasma and liver tissues upon oral administration. Therapeutic dosing of PAT-505 in Stelic mice model of non-alcoholic steatohepatitis (NASH) resulted in a modest but significant improvement in fibrosis, with only slight improvements in hepatocyte ballooning and liver inflammation. In choline-deficient, high-fat NASH diet model, PAT-505 treatment effectively reduced liver fibrosis, without significant effects on steatosis, hepatocyte ballooning, or inflammation[1].

Molecular Weight	473.92
Formula	C23H18ClF2N3O2S
CAS No.	1782070-22-7

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (63.30 mM), Sonication is recommended.

References and Literature

1. Bain G, et al. Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis. J Pharmacol Exp Ther. 2017 Jan;360(1):1-13. Epub 2016 Oct 17.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PAT-505 1782070-22-7 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR PAT505 PAT 505 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.