pharmacokinetics — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T15712	Laropiprant	MK-0524	Prostaglandin Receptor
	Laropiprant (MK-0524) is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM).		Prostaglandin Receptor
T8441	Lerisetron		5-HT Receptor
	Lerisetron is an antagonist of serotonin type 3 (5-HT3) receptor, with antiemetic activity.		5-HT Receptor
T1752	NS6180		Potassium Channel
	NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation.		Potassium Channel
T7121	Sulfaclozine	Sulfachloropyrazine,Sulfachloropyrazine sodium	Antibacterial , Antibiotic , Parasite
	Sulfachloropyrazine sodium(Sulfachloropyrazine) is an antiprotozoal,with antibacterial and anticoccidial effects		Antibacterial , Antibiotic , Parasite
T8405	Vardenafil hydrochloride		PDE
	Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes		PDE
T0096	Vardenafil	Vivanza,Levitra,Vardenafil hydrochloride	PDE
	Vardenafil (Vivanza) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemod...		PDE
T4097	Vardenafil hydrochloride trihydrate	Vardenafil HCl Trihydrate,BAY38-9456	PDE
	Vardenafil hydrochloride trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.		PDE
T4480	Vardenafil dihydrochloride	Levitra,Vardenafil Hydrochloride	PDE
	Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.		PDE
T22249	1588-A4	ARS-1620 Intermediate	Ras
	1588-A4 (ARS-1620 Intermediate) is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.		Ras
T36020	Florfenicol amine (hydrochloride)
	Florfenicol amine is a major metabolite of the antibiotic florfenicol, a fluorinated derivative of chloramphenicol that is commonly used in veterinary medicine. The pharmacokinetics of florfenicol and florfenicol amine a...
T25824	ML400	ML 400,CID-73050863,ML-400,CID73050863,CID 73050863	Phosphatase
	ML400 (CID73050863) is an allosteric inhibitor of LMPTP with an EC50 of 1μM. ML400 displays good cell-based activity and rodent pharmacokinetics.		Phosphatase
T2006	Omecamtiv mecarbil	CK-1827452	ATPase , Myosin
	Omecamtiv mecarbil (CK-1827452) has been used in trials studying the treatment and basic science of Heart Failure, Echocardiogram, Pharmacokinetics, Chronic Heart Failure, and History of Chronic Heart Failure, among othe...		ATPase , Myosin
T6705	TIC10 Isomer	ONC201 isomer,TIC10 Analogue	Others
	TIC10 Isomer (ONC201 isomer) is an isomer of TIC10, which inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improv...		Others
T7001	TIC10	ONC-201	Apoptosis , TNF
	TIC10 (ONC-201) inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.		Apoptosis , TNF
T20570	Labetalol	Apo-Labetalol,Albetol,Trandate,Dilevalol,Normodyne	Adrenergic Receptor
	Labetalol (Apo-Labetalol) is a mixed alpha/beta-adrenergic antagonist.It is used to treat high blood pressure. It can be given by mouth for long term hypertension management or intravenously in severe hypertensive situat...		Adrenergic Receptor
T8947	Dasiglucagon acetate	dasiglucagon acetate(1544300-84-6 free base)	Others
	Dasiglucagon acetate is a novel glucagon analog for diabetic hypoglycemia therapy. Dasiglucagon acetate has demonstrated established solubility and stability in an aqueous formulation. Pharmacokinetics studies have shown...		Others
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T36520	COR659		Cannabinoid Receptor , GABA Receptor
	COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effects via a composite mechanism, including positive allosteri...		Cannabinoid Receptor , GABA Receptor
T39124	BAY 1217224
	BAY 1217224 is a neutral, non-prodrug Thrombin inhibitor with good oral pharmacokinetics.
T30514	BMS-344577	U259PQB19A,UNII-U259PQB19A,CHEMBL570867,BMS 344577
	BMS-344577, a lactam derivative based on arylguanidine, is a potent oral active FXA inhibitor with excellent susceptibility in vitro, good pharmacokinetics, and pharmacodynamics in animal models.