overload — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1457	Deferasirox	ICL 670,CGP-72670	Others , Ferroptosis , Antibacterial
	Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.		Others , Ferroptosis , Antibacterial
T19692	Deferitrin	GT 56252,GT 56 252,GT-56252,GT-56-252	Others
	Deferitrin (GT-56-252) is an iron chelator. It potentially for the treatment of thalassemia and iron overload.		Others
T32046	HBED	CHELII,CHEL II,CHEL-II	Others
	HBED (CHELII) is an iron chelator and can be used in research on the treatment of chronic iron overload and acute iron poisoning.		Others
T20819	Ammonium iron(III) citrate	Ferric ammonium citrate	Others , Ferroptosis
	Ammonium iron(III) citrate (Ferric ammonium citrate) is a physiological form of non-ferritin-bound iron that causes intracellular iron overload leading to cellular iron death and enhances protein production.		Others , Ferroptosis
T10874	CP-060		Calcium Channel
	CP-060 is a potent Ca2+ antagonist and inhibits Ca2+ overload with antioxidant and cardioprotective activities.		Calcium Channel
T13639	Deferasirox (Fe3+ chelate)		Apoptosis
	Deferasirox (Fe3+ chelate) is an orally available iron chelator with potential anticancer activity, inhibits the anti-apoptotic activity of MCL-1, and can be used to study iron overload.		Apoptosis
TWP2911	Thymidine	5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin	Others , DNA/RNA Synthesis , Endogenous Metabolite
	1. Thymidine (DThyd) overload due to Thymidine phosphorylase deficiency, and mitochondrial toxicity caused by antiviral Thymidine analogues.		Others , DNA/RNA Synthesis , Endogenous Metabolite
T8891	Homo-VK-II-36	Homo-V-II-36	Others
	Homo-VK-II-36 (Homo-V-II-36) is a carvedilol analogue that acts by inhibiting store- overload-induced calcium release through the RyR2 channel.		Others
TN5073	Strophanthidin	Strophanthidine	ATPase , Calcium Channel
	Strophanthidin (Strophanthidine) can induce calcium overload in vivo.		ATPase , Calcium Channel
TN2082	Pinostrobin		Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF
	Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppress...		Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF
T3415	Secoisolariciresinol diglucoside	LGM2605	ROS
	Secoisolariciresinol diglucoside (LGM2605) was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage. Secoisolariciresinol diglucoside (25 mg/kg b.w.) exerts the antihyperglycemic effect ...		ROS
T68284	NP-04634
	NP-04634 is a calcium antagonist and protective agent against calcium overload and mitochondrial disruption.
T40694	4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid
	4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid exhibits hypoglycemic activity and operates through a mechanism dependent on the response to oral glucose overload.
T31363	Deferitazole magnesium	FBS0701,FBS-0701,SSP-004184,SHP-602,SHP602,Deferitazole free base
	Deferitazole magnesium is a potential chelator for iron overload treatment.
TN1086	Dehydrotrametenolic acid	Dehydroeburicoic acid	Apoptosis , TNF , NOS , Caspase , NO Synthase
	Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas.		Apoptosis , TNF , NOS , Caspase , NO Synthase
T64249	CYP11B1-IN-2
	CYP11B1-IN-2 (compound 7aa) is a selective, orally active inhibitor of CYP11B1 that acts on human CYP11B1 (IC50: 9 nM) and rat CYP11B1 (IC50: 25 nM). CYP11B1-IN-2 can be used to study diseases caused by cortisol overload...