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Ammonium iron(III) citrate

Catalog No. T20819 CAS 1185-57-5

Synonyms: Ferric ammonium citrate

Ammonium iron(III) citrate (Ferric ammonium citrate) is a physiological form of non-ferritin-bound iron that causes intracellular iron overload leading to cellular iron death and enhances protein production.

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Ammonium iron(III) citrate Chemical Structure

Ammonium iron(III) citrate, CAS 1185-57-5

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Ferric ammonium citrate
Molecular Weight	978.05
Formula	C24H32Fe3N3O28
CAS No.	1185-57-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 33.33 mg/mL, Sonication is recommended.

DMSO: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Pogge DJ, Drewnoski ME, Hansen SL. Feeding ferric ammonium citrate to decrease the risk of sulfur toxicity: effects on trace mineral absorption and status of beef steers. J Anim Sci. 2014 Sep;92(9):4005-13. doi: 10.2527/jas.2014-7799. Epub 2014 Jul 8. PubMed PMID: 25006066. 2. Chavasit V, Porasuphatana S, Suthutvoravut U, Zeder C, Hurrell R. Iron bioavailability in 8-24-month-old Thai children from a micronutrient-fortified quick-cooking rice containing ferric ammonium citrate or a mixture of ferrous sulphate and ferric sodium ethylenediaminetetraacetic acid. Matern Child Nutr. 2015 Dec;11 Suppl 4:179-87. doi: 10.1111/mcn.12167. PubMed PMID: 25721887. 3. Pogge DJ, Drewnoski ME, Snider D, Rumbeiha WK, Hansen SL. Effect of ferric ammonium citrate in feedlot diets with varying dried distillers' grains inclusion on ruminal hydrogen sulfide concentrations and steer growth. J Anim Sci. 2016 Sep;94(9):3894-3901. doi: 10.2527/jas.2016-0657. PubMed PMID: 27898902. 4. Li SW, Liu CM, Guo J, Marcondes AM, Deeg J, Li X, Guan F. Iron overload induced by ferric ammonium citrate triggers reactive oxygen species-mediated apoptosis via both extrinsic and intrinsic pathways in human hepatic cells. Hum Exp Toxicol. 2016 Jun;35(6):598-607. doi: 10.1177/0960327115597312. Epub 2015 Jul 29. PubMed PMID: 26224043.

Citations

1. Zhang Z, Yuan Q, Hu X, et al. Rifaximin protects SH‐SY5Y neuronal cells from iron overload‐induced cytotoxicity via inhibiting STAT3/NF‐κB signaling. Cell Biology International.. 2. Tan Q, Wu D, Lin Y, et al.Identifying eleven new ferroptosis inhibitors as neuroprotective agents from FDA-approved drugs.Bioorganic Chemistry.2024: 107261.

Related compound libraries

This product is contained In the following compound libraries：

RO5 Drug-like Natural Product Library Food Additive Library

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Keywords

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