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Homo-VK-II-36

Catalog No. T8891   CAS 1479049-35-8
Synonyms: HomoVKII36, Homo VK II 36, Homo-V-II-36

Homo-VK-II-36 is a carvedilol analogue that acts by inhibiting store-​overload-induced calcium release through the RyR2 channel.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Homo-VK-II-36, CAS 1479049-35-8
Pack Size Availability Price/USD Quantity
1 mg In stock 134.00
5 mg In stock 302.00
10 mg In stock 453.00
25 mg In stock 817.00
50 mg In stock 1225.00
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Purity 99.26%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Homo-VK-II-36 is a carvedilol analogue that acts by inhibiting store-​overload-induced calcium release through the RyR2 channel.
Synonyms HomoVKII36 , Homo VK II 36 , Homo-V-II-36
Purity 99.26%
Molecular Weight 460.53
Formula C27H28N2O5
CAS No. 1479049-35-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Zhang JZ, McLay JC, Jones PP. The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+). J Mol Cell Cardiol. 2014 Sep;74:22-31. doi: 10.1016/j.yjmcc.2014.04.019. Epub 2014 May 5. PubMed PMID: 24805197. 2. Zhou Q, Xiao J, Jiang D, et al. Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med. 2011 Jul 10;17(8):1003-9. doi: 10.1038/nm.2406. PubMed PMID: 21743453; PubMed Central PMCID: PMC3268079.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.