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Homo-VK-II-36

Catalog No. T8891 CAS 1479049-35-8

Synonyms: HomoVKII36, Homo VK II 36, Homo-V-II-36

Homo-VK-II-36 is a carvedilol analogue that acts by inhibiting store-overload-induced calcium release through the RyR2 channel.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Homo-VK-II-36, CAS 1479049-35-8

Pack Size	Availability	Price/USD
1 mg	In stock	134.00
5 mg	In stock	302.00
10 mg	In stock	453.00
25 mg	In stock	817.00
50 mg	In stock	1225.00

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Purity 99.26%

HNMR HPLC COA

Datasheet

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Homo-VK-II-36 is a carvedilol analogue that acts by inhibiting store-overload-induced calcium release through the RyR2 channel.

Synonyms	HomoVKII36 , Homo VK II 36 , Homo-V-II-36
Purity	99.26%
Molecular Weight	460.53
Formula	C27H28N2O5
CAS No.	1479049-35-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Zhang JZ, McLay JC, Jones PP. The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+). J Mol Cell Cardiol. 2014 Sep;74:22-31. doi: 10.1016/j.yjmcc.2014.04.019. Epub 2014 May 5. PubMed PMID: 24805197. 2. Zhou Q, Xiao J, Jiang D, et al. Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med. 2011 Jul 10;17(8):1003-9. doi: 10.1038/nm.2406. PubMed PMID: 21743453; PubMed Central PMCID: PMC3268079.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.