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Homo-VK-II-36

Catalog No. T8891 CAS 1479049-35-8

Synonyms: Homo-V-II-36

Homo-VK-II-36 (Homo-V-II-36) is a carvedilol analogue that acts by inhibiting store- overload-induced calcium release through the RyR2 channel.

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Homo-VK-II-36, CAS 1479049-35-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 84.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 313.00
25 mg	In stock	$ 533.00
50 mg	In stock	$ 768.00
100 mg	In stock	$ 1,080.00
1 mL * 10 mM (in DMSO)	In stock	$ 198.00

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Purity: 99.26%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Homo-VK-II-36 (Homo-V-II-36) is a carvedilol analogue that acts by inhibiting store- overload-induced calcium release through the RyR2 channel.

Synonyms	Homo-V-II-36
Molecular Weight	460.52
Formula	C27H28N2O5
CAS No.	1479049-35-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.61 mg/mL (10 mM)

References and Literature

1. Zhang JZ, McLay JC, Jones PP. The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+). J Mol Cell Cardiol. 2014 Sep;74:22-31. doi: 10.1016/j.yjmcc.2014.04.019. Epub 2014 May 5. PubMed PMID: 24805197. 2. Zhou Q, Xiao J, Jiang D, et al. Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med. 2011 Jul 10;17(8):1003-9. doi: 10.1038/nm.2406. PubMed PMID: 21743453; PubMed Central PMCID: PMC3268079.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Ion Channel Inhibitor Library NO PAINS Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Homo-VK-II-36 1479049-35-8 Others Homo VK II 36 HomoVKII36 Homo-V-II-36 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.