organ — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T19777	ODQ		Apoptosis , Others , Guanylate cyclase
	ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.		Apoptosis , Others , Guanylate cyclase
T12783	RWJ 50271		Integrin
	RWJ 50271 is a selective lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction inhibitor( IC50 of 5.0 μM in HL60 cells).		Integrin
T20812	Azamethiphos		AChE
	Azamethiphos, an organothiophosphate insecticide, is used in Atlantic salmon fish farming to control parasites.		AChE
T76173	Inorganic pyrophosphatase
	Inorganic pyrophosphatase (PPase), key for RNA preparation in in vitro transcription reactions and critical in biochemical studies for nucleic acid and protein synthesis [1], hydrolyzes pyrophosphate (PPi) into phosphate...
T10009	JAK3-IN-7		JAK
	JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction after organ transplantation, autoimmune disorders, allergic diseases, ...		JAK
T6459	Cyclosporine		Phosphatase
	Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.		Phosphatase
T11318	Dopexamine hydrochloride	FPL60278AR	Adrenergic Receptor
	Dopexamine hydrochloride (FPL60278AR) is a β2-adrenergic receptor agonist. Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regi...		Adrenergic Receptor
T17105	TM6089		HIF/HIF Prolyl-Hydroxylase
	TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.		HIF/HIF Prolyl-Hydroxylase
T13187	Topterone	Win 17665	Androgen Receptor
	Topterone (Win 17,665) is a potent topical antiandrogen that inhibits the stimulation of lumbar organ development by testosterone and dihydrotestosterone in castrated immature male hamsters.		Androgen Receptor
T60144	TDI-011536		Others
	TDI-011536, a potent Lats kinase inhibitor, disrupts Hippo-Yap signaling and promotes the proliferation of lesioned heart muscle cells. This compound is valuable for research in organ conservation and regeneration.		Others
T21334	Bucillamine	DE-019,Thiobutarit,Tiobutarit,SA96,DE 019,DE019	VEGFR , Antioxidant
	Bucillamine (DE019) protects against Ischemia/reperfusion injury in high-risk organ transplants and inhibits the production of VEGF. Bucillamine is an orally active sulfhydryl donor and antioxidant with antirheumatic and...		VEGFR , Antioxidant
T31615	Elsibucol	AGI-1096,UNII-O7T92N1Y8T,AGI 1096	Antioxidant
	Elsibucol (AGI 1096) is a VCAM1 inhibitor for the study of organ transplant rejection.Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. It lowe...		Antioxidant
T76830	Teneliximab	Chi220,Anti-Human CD40 Recombinant Antibody,BMS 224819	TNF
	Teneliximab (Chi220) is a chimeric monoclonal antibody and a tumor necrosis factor receptor superfamily member 5 (CD40) inhibitor that blocks CD40-CD40L interactions.Teneliximab exerts partial agonist activity through CD...		TNF
T74485	STC314		Others
	STC314 is an anti-infective agent that reverses organ damage caused by excessive immune response by neutralizing extracellular histones and neutrophil trapping networks, and can be used in the study of sepsis and acute r...		Others
T19722	Benazeprilat	CGS14831,CGS-14831,CGS 14831	RAAS , Endogenous Metabolite
	Benazeprilat(CGS 14831) is an orally active active metabolite of Benazepril.Benazeprilat has potent antihypertensive activity and can be used in combination with other classes of compounds, including thiazide diuretics a...		RAAS , Endogenous Metabolite
T4752	1-Aminocyclopropane-1-carboxylic acid	1-Aminocyclopropanecarboxylic acid,1-Amino-1-carboxycyclopropane,ACC	Endogenous Metabolite , NMDAR
	1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecul...		Endogenous Metabolite , NMDAR
T9543	Syk Inhibitor II hydrochloride		Others
	The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of...		Others
T4723	D-Tagatose	D-(-)-Tagatose,d-tagatos	Others , Endogenous Metabolite
	D-Tagatose (D-(-)-Tagatose), a rare natural hexoketose, is an isomer of d-galactose. D-Tagatose occurs naturally in Sterculia setigera gum, and it is also found in small quantities in various foods such as sterilized and...		Others , Endogenous Metabolite
T69431	A-420983
	A-420983 is a novel potent Lck inhibitor, exhibiting oral efficacy in animal models of delayed-type hypersensitivity and organ transplant rejection.
T38672	VTP-27999 Hydrochloride
	VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases. IC50 value: Target: Renin