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Elsibucol

Catalog No. T31615   CAS 216167-95-2
Synonyms: AGI-1096, UNII-O7T92N1Y8T, AGI 1096

Elsibucol (AGI 1096) is a VCAM1 inhibitor for the study of organ transplant rejection.Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. It lowers blood cholesterol levels and reduces oxidative stress and inflammatory responses in injured arteries, thereby inhibiting atherosclerosis and protecting endothelial healing after arterial injury.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Elsibucol Chemical Structure
Elsibucol, CAS 216167-95-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 146.00
5 mg In stock $ 350.00
10 mg In stock $ 530.00
25 mg In stock $ 859.00
50 mg In stock $ 1,180.00
100 mg In stock $ 1,590.00
500 mg In stock $ 3,190.00
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Purity: 98.97%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Elsibucol (AGI 1096) is a VCAM1 inhibitor for the study of organ transplant rejection.Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. It lowers blood cholesterol levels and reduces oxidative stress and inflammatory responses in injured arteries, thereby inhibiting atherosclerosis and protecting endothelial healing after arterial injury.
In vitro AGI-1096 (0-20 μM) inhibited the inducible expression of vascular cell adhesion molecule (VCAM)-1, E-selectin, and monocyte chemoattractant protein (MCP)-1 in endothelial cells and tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta secretion from lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells. It also inhibited the serum-stimulated proliferation of aortic smooth muscle cells.[4]
In vivo Elsibucol (0.5%, 1%; feed; arterial injury in rabbits with hypercholesterolemia; 3 weeks) significantly decreases blood total cholesterol, LDLc, and triglyceride levels. This is associated with a significant 46% reduction of neointimal hyperplasia following arterial injury. Interestingly, the effect of Elsibucol on cholesterol levels and neointimal formation appears to be more pronounced than that of probucol. Treatment with Elsibucol is associated with a significant reduction of cellular proliferation (PCNA immunostaining), oxidative stress (nitrotyrosine immunostaining), VCAM-1 expression, and macrophage infiltration in injured arteries. Despite its potent effect on neointimal hyperplasia, Elsibucol does not prevent endothelial healing (Evans blue staining) following arterial injury. CONCLUSIONS: In hypercholesterolemic animals, Elsibucol inhibits atherosclerosis and preserves endothelial healing following arterial injury.[1]
Synonyms AGI-1096, UNII-O7T92N1Y8T, AGI 1096
Molecular Weight 602.93
Formula C35H54O4S2
CAS No. 216167-95-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Dussault S, et al. Elsibucol inhibits atherosclerosis following arterial injury: multifunctional effects on cholesterol levels, oxidative stress and inflammation. Atherosclerosis. 2014 Nov;237(1):194-9. 2. First MR, et al. New drugs to improve transplant outcomes. Transplantation. 2004;77(9 Suppl):S88-S92. 3. LI T, et al. Effect and Possible Mechanism of Elsibucol Inhibiting Atherosclerosis in Experimental Rabbits. Chinese Circulation Journal. 2016: 449-453. 4. Murata S, et al. Effects of AGI-1096, a novel antioxidant compound with anti-inflammatory and antiproliferative properties, on rodent allograft arteriosclerosis. Transplantation. 2004 May 27;77(10):1494-500.

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Keywords

Elsibucol 216167-95-2 oxidation-reduction Antioxidant AGI1096 AGI-1096 UNII-O7T92N1Y8T AGI 1096 inhibitor inhibit

 

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