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Elsibucol

Catalog No. T31615 CAS 216167-95-2

Synonyms: AGI-1096, UNII-O7T92N1Y8T, AGI 1096

Elsibucol (AGI 1096) is a VCAM1 inhibitor for the study of organ transplant rejection.Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. It lowers blood cholesterol levels and reduces oxidative stress and inflammatory responses in injured arteries, thereby inhibiting atherosclerosis and protecting endothelial healing after arterial injury.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Elsibucol, CAS 216167-95-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 146.00
5 mg	In stock	$ 350.00
10 mg	In stock	$ 530.00
25 mg	In stock	$ 859.00
50 mg	In stock	$ 1,180.00
100 mg	In stock	$ 1,590.00
500 mg	In stock	$ 3,190.00

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Purity: 98.97%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Elsibucol (AGI 1096) is a VCAM1 inhibitor for the study of organ transplant rejection.Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. It lowers blood cholesterol levels and reduces oxidative stress and inflammatory responses in injured arteries, thereby inhibiting atherosclerosis and protecting endothelial healing after arterial injury.
In vitro	AGI-1096 (0-20 μM) inhibited the inducible expression of vascular cell adhesion molecule (VCAM)-1, E-selectin, and monocyte chemoattractant protein (MCP)-1 in endothelial cells and tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta secretion from lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells. It also inhibited the serum-stimulated proliferation of aortic smooth muscle cells.[4]
In vivo	Elsibucol (0.5%, 1%; feed; arterial injury in rabbits with hypercholesterolemia; 3 weeks) significantly decreases blood total cholesterol, LDLc, and triglyceride levels. This is associated with a significant 46% reduction of neointimal hyperplasia following arterial injury. Interestingly, the effect of Elsibucol on cholesterol levels and neointimal formation appears to be more pronounced than that of probucol. Treatment with Elsibucol is associated with a significant reduction of cellular proliferation (PCNA immunostaining), oxidative stress (nitrotyrosine immunostaining), VCAM-1 expression, and macrophage infiltration in injured arteries. Despite its potent effect on neointimal hyperplasia, Elsibucol does not prevent endothelial healing (Evans blue staining) following arterial injury. CONCLUSIONS: In hypercholesterolemic animals, Elsibucol inhibits atherosclerosis and preserves endothelial healing following arterial injury.[1]

Synonyms	AGI-1096, UNII-O7T92N1Y8T, AGI 1096
Molecular Weight	602.93
Formula	C35H54O4S2
CAS No.	216167-95-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (82.93 mM)

References and Literature

1. Dussault S, et al. Elsibucol inhibits atherosclerosis following arterial injury: multifunctional effects on cholesterol levels, oxidative stress and inflammation. Atherosclerosis. 2014 Nov;237(1):194-9. 2. First MR, et al. New drugs to improve transplant outcomes. Transplantation. 2004;77(9 Suppl):S88-S92. 3. LI T, et al. Effect and Possible Mechanism of Elsibucol Inhibiting Atherosclerosis in Experimental Rabbits. Chinese Circulation Journal. 2016: 449-453. 4. Murata S, et al. Effects of AGI-1096, a novel antioxidant compound with anti-inflammatory and antiproliferative properties, on rodent allograft arteriosclerosis. Transplantation. 2004 May 27;77(10):1494-500.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Bioactive Compound Library

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Keywords

Elsibucol 216167-95-2 oxidation-reduction Antioxidant AGI1096 AGI-1096 UNII-O7T92N1Y8T AGI 1096 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.