on-target — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3626	Acalabrutinib	ACP-196	BTK
	Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and pre...		BTK
T15444	GSK962		Others
	GSK962 is a GSK963 inactive enantiomer. It can be used to confirm the on-target effects.		Others
T77191	Clivatuzumab		Others
	Clivatuzumab is a humanized anti-myxinomab, which can target the MUC1 epitope highly expressed on the surface of most pancreatic cancer cells, and has a good therapeutic effect on a variety of tumor cells.		Others
T9853	STING activator Compound 53		STING
	STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint cons...		STING
T8984	FLTX1		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	FLTX1 is a fluorescent derivative of Tamoxifen, designed to efficiently target and label intracellular Tamoxifen-binding sites (estrogen receptors) both under permeabilized and non-permeabilized conditions. Additionally,...		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T9127	MYLS22		Others
	MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) . MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene exp...		Others
T67930L	CWI1-2 HCL		Apoptosis
	CWI1-2 HCL is an effective IGF2BP2 inhibitor, which can induce apoptosis and differentiation by binding IGF2BP2 and inhibiting its interaction with M6A-modified target transcription, and has therapeutic effects on leukem...		Apoptosis
T0520	Lenvatinib	E7080	VEGFR , FGFR , c-RET , PDGFR , c-Kit
	Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity. Lenvatinib has the strongest inhibitory activity on VEGFR2 and VEGFR3 (...		VEGFR , FGFR , c-RET , PDGFR , c-Kit
T17870	CIAP1 ligand 1	E3 ligase Ligand 12	Others
	cIAP1 ligand 1 (E3 ligase Ligand 12) is an apoptotic protein ligand based on the LCL161 derivative that recruits IAP ubiquitin ligases to degrade target proteins, and can be used to couple with androgen receptor ligands ...		Others
T12831L	SAR405		PI3K , Autophagy
	SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by sta...		PI3K , Autophagy
T36083	DS-7423		PI3K , mTOR
	DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2]. DS-7423 increases TP53 expression, the level of p-TP53 on Ser...		PI3K , mTOR
T20658	Etofenprox
	Etofenprox, a synthetic pyrethroid, has insecticidal efficacy against mosquito larvae & on non-target organisms.
T69777	DKFZ-251
	DKFZ-251 is a potent inhibitor of kallikrein-related peptidase 6 with on-target cellular activity. DKFZ-251 demonstrated good selectivity for KLK6 compared to other KLKs, and on-target activity in a cellular assay.
T71197	JW-7-25-1
	JW-7-25-1 is a potent multi-target inhibitor, acting on MELK, PIK3CA, mTOR, GSK3A and CDK7.
T22860	Imeglimin		Others
	Imeglimin is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents. It has been shown to act on the liver, muscle, and pancreatic β-cells to uniquely target the key defects of type 2 diabetes...		Others
T19989	Imazamethabenz	Imazamethabenz-methyl,Assert,HSDB 6675,Dagger
	Imazamethabenz is a herbicide. Imazamethabenz-methyl is used on cereals and sunflowers, especially against wild oat. Activity and selectivity are due to differential de-esterification to the active parent acid in target ...
T76881	Teclistamab
	Teclistamab, a human bispecific antibody targeting both BCMA on target cells and CD3 on T cells, facilitates T cell-mediated cytotoxicity, which results in T cell activation and subsequent target cell lysis. This compoun...
T14105	Acid-PEG4-C2-Boc		Others
	Acid-PEG4-C2-Boc is a linker compound based on polyethylene glycol (PEG) and alkyl/ether. It is utilized in the synthesis of PROteolysis TArgeting Chimeras (PROTACs) for the purpose of inhibiting the mechanistic Target o...		Others
T16578	PRN694		Others
	PRN694 shows extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo. PRN694 is an irreversible, highly selective, and effective covalent interleukin-2-inducible...		Others
T77012	Flotetuzumab
	Flotetuzumab (MGD006; S80880), an investigational CD123/CD3 bispecific dual-affinity retargeting antibody (DART) molecule, reactivates T cells through concurrent engagement with CD123 on target cells and CD3 on effector ...