obese — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9193	ACH-000143		Melatonin Receptor , MT Receptor
	ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.		Melatonin Receptor , MT Receptor
T21902	ML351		Lipoxygenase
	ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).		Lipoxygenase
T8676	FOY 251		Others , Serine/threonin kinase , SARS-CoV
	FOY 251 is a proteinase inhibitor, and is an anti-proteolytic active metabolite camostate.		Others , Serine/threonin kinase , SARS-CoV
T0839	Ketoprofen	RP-19583	Apoptosis , COX , MRP
	Ketoprofen (RP-19583) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenas...		Apoptosis , COX , MRP
T26986	Cevoglitazar	LBM-642,LBM 642,LBM642	PPAR
	Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.		PPAR
T24121	GW438014A	GW 438014 A,GW-438014-A	Neuropeptide Y Receptor
	GW438014A is a potent, selective antagonist of the NPY-Y5 receptor, effectively inhibiting food consumption and curbing body weight gain in obese rodents.		Neuropeptide Y Receptor
T15679	L 152804		Neuropeptide Y Receptor
	L 152804 is a specific antagonist of the neuropeptide Y Y5 receptor and modulates food intake and energy expenditure thus causing weight loss in diet-induced obese mice.		Neuropeptide Y Receptor
T17303	α-Cyclodextrin	Alfadex,NSC269470,NSC 269470,NSC-269470	Others
	α-Cyclodextrin (Alfadex) is a soluble fiber derived from corn and has beneficial effects on weight management in obese individuals with type 2 diabetes.		Others
T4785	Oxfenicine	4-Hydroxy-L-phenylglycine	Others
	Oxfenicine (4-Hydroxy-L-phenylglycine) is a carnitine palmitoyltransferase-1 inhibitor. Oxfenicine improves whole-body glucose tolerance and insulin sensitivity in high-fat diet-induced obese mouse with insulin resistanc...		Others
TP2047L	CRF (6-33) acetate(120066-38-8 free base)		CRFR
	CRF (6-33) acetate is a corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide; displaces CRF from CRFBP. Suppresses body weight gain and increases motor activity in obese rats in vivo.		CRFR
TP1913L1	BA 1 acetate(183241-31-8 free base)		Bombesin Receptor
	BA 1 acetate is a potent bombesin receptor agonist (IC50 values are 0.26, 1.55 and 2.52 nM for BB1, BB2 and BB3 respectively). Enhances glucose transport in obese and diabetic primary myocytes. Also stimulates NCI-H1299 ...		Bombesin Receptor
T4681	T863	DGAT-3,DGAT-1 inhibitor	Acyltransferase , Transferase
	T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis...		Acyltransferase , Transferase
T38074	Thiodigalactoside		Galectin
	Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM for GAL1 and GAL3, respectively. Demonstrating anti-inflamma...		Galectin
T2S2173	(E)-Naringenin chalcone	Isosalipurpol,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone	Others
	Naringenin chalcone (Isosalipurpol) has antiallergic activity Naringenin chalcone suppresses asthmatic symptoms by inhibiting Th2 cytokine production from CD4 T cells. Naringenin chalcone is a potent tomato flavonoid tha...		Others
T3685	SR9009	Stenabolic,REV-ERB Agonist II	Autophagy
	SR9009 (Stenabolic), a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009 can decrease circadian locomotor activity during...		Autophagy
TP1930L1	Spexin acetate(1370290-58-6 free base)		Neuropeptide Y Receptor
	Spexin acetate is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits...		Neuropeptide Y Receptor
TP1679	BDC2.5 mimotope 1040-51
	BDC2.5 mimotope 1040-51 is a mimotope peptide for diabetogenic T cell clone BDC2.5. isolated from non-obese diabetic mice.This is a effectively agonistic peptide (mimotope) for diabetogenic T cell clone BDC2.5. from non-...
T10613	BRL 37344 sodium	BRL 37344A	Others
	BRL 37344 sodium is a specific agonist of the β3-adrenergic receptor. The treatment of BRL 37344 sodium significantly lowers the bodyweight of obese mice.		Others
TP2047	CRF(6-33)(human)	CRF (6-33)
	CRF(6-33)(human) is a Corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide; displaces CRF from CRFBP. Suppresses body weight gain and increases motor activity in obese rats in vivo.
T10044	13-Oxo-9E,11E-octadecadienoic acid		PPAR
	13-Oxo-9E,11E-octadecadienoic acid, a potent PPARα activator derived from tomato juice and an isomer of 9-oxo-ODA, exhibits the ability to decrease plasma and hepatic triglyceride levels in obese diabetic mice[1].		PPAR