muscular — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39516	Bocidelpar		PPAR
	Bocidelpar is a modulator of PPARδ with an EC50 of 7.80 nM and improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy muscle cells.		PPAR
T7837	SR8278		Others
	SR8278 is an REV-ERBα antagonist(EC50 = 0.47 µM), blocking activation of the receptor by the synthetic agonist GSK 4112		Others
T17217	Vamorolone	VBP15	Glucocorticoid Receptor , NF-κB
	Vamorolone (VBP15) is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone displays effective NF-κB inhibition an...		Glucocorticoid Receptor , NF-κB
T4641	Branaplam	LMI 070,NVS-SM1	Others , Potassium Channel , DNA/RNA Synthesis
	Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.		Others , Potassium Channel , DNA/RNA Synthesis
T16545	Pivanex	Pivalyloxymethyl butyrate,AN-9	Apoptosis , HDAC , Bcr-Abl
	Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.		Apoptosis , HDAC , Bcr-Abl
T3424	Ezutromid	BMN 195,VOX-C1100,SMT C1100	Others
	Ezutromid (BMN 195) is a translation modulator of Small utrophin (EC50: 0.4 uM). Ezutromid is an orally bioavailable small molecule that transcriptionally upregulates the utrophin gene, increasing both utrophin mRNA and ...		Others
T13491	Neuromuscular-targeting compound 1		Others
	Neuromuscular-targeting compound 1 can be used to study muscular dystrophy and neuromuscular-related diseases.		Others
T10059	Neuromuscular Disorder-Targeting Compound 1		Others
	Neuromuscular Disorder-Targeting Compound 1 is a compound used in the research of neuromuscular disorders, for example, symptoms of chronic fatigue syndrome and fibromyalgia syndrome.		Others
T7722	Feprazone	Prenazone,DA 2370,DA2370,DA-2370	Others
	Feprazone (DA-2370) possesses anti-inflammatory and antiadipogenic properties. Feprazone can be used in studies about the treatment of joint and muscular pain.		Others
T3336	Rg3039	PF-06687859	Others
	Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an...		Others
T12718L	RG7800	RO6885247	Others , DNA/RNA Synthesis
	RG7800 (RO6885247) has the potential for spinal muscular atrophy treatment. RG7800 is an SMN2 splicing modifier.		Others , DNA/RNA Synthesis
T12935	SMN-C3	MV8T2MCK57	DNA/RNA Synthesis
	SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA).		DNA/RNA Synthesis
T2553	Etofenamate		COX
	Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.		COX
T9821	ART-CHEM-BB B025267		Others
	ART-CHEM-BB B025267 is the upregulator of utrophin production with EC50 of 1.8 μM and can be used in research on the treatment of Duchenne muscular dystrophy.		Others
T1805	Ataluren	PTC124	CFTR , Autophagy
	Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and olde...		CFTR , Autophagy
T0319	Suxibuzone	Calibene,Suxibuzonum,Suxibuzona	COX
	Suxibuzone (Suxibuzona) is a drug used for joint and muscular pain. It is a prodrug of the non steroidal anti inflammatory drug phenylbutazone, and is commonly used in horses.		COX
T0399	Methyl salicylate	Gaultheria oil,Methyl 2-hydroxybenzoate,2-Carbomethoxyphenol,Betula oil,Natural wintergreen oil,Wintergreen oil	COX , TRP/TRPV Channel
	Methyl salicylate (Gaultheria oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic ...		COX , TRP/TRPV Channel
T72072	2-benzylsulfanyl-6-methoxy-4-methylquinazoline		ROS
	2-benzylsulfanyl-6-methoxy-4-methylquinazoline can be used as a TRPML modulator for the treatment of diseases associated with TRPML activity, such as lysosomal storage disease, muscular dystrophy, oxidative stress or rea...		ROS
T77445	Apitegromab	SRK-015	Opioid Receptor
	Apitegromab (SRK-015) is a new myostatin inhibitor, an antibody targeting myostatin precursor, which can be used to study neuromuscular diseases including spinal muscular atrophy.		Opioid Receptor
T15945	MA-0204		PPAR
	MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively). It is a potential treatmen...		PPAR