Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vamorolone (VBP15) is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone displays effective NF-κB inhibition and substantially decreases hormonal effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 113.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 313.00 | |
100 mg | In stock | $ 468.00 | |
200 mg | In stock | $ 673.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | Vamorolone (VBP15) is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone displays effective NF-κB inhibition and substantially decreases hormonal effects. |
In vitro | Vamorolone is a first-in-class mineralocorticoid receptor antagonist/dissociative glucocorticoid receptor ligand. Vamorolone inhibits TNFα-induced pro-inflammatory NF-κB signaling in C2C12 muscle cells at 1 nM or more. Vamorolone binds the glucocorticoid receptor and mineralocorticoid receptor. Vamorolone (0.1, 1μM; 30 minutes) decreases the production of IL1βand CCL5 inflammatory mediators in primary human macrophages [1][2][3]. |
In vivo | Vamorolone (30 mg/kg; p.o.; daily for 20 days) decreases CNS Inflammation in murine experimental autoimmune encephalomyelitis. Vamorolone (5-30 mg/kg; cherry syrup) displays a superior side effect profile compared to pharmacological glucocorticoids in mdx mice [1][2]. |
Synonyms | VBP15 |
Molecular Weight | 356.46 |
Formula | C22H28O4 |
CAS No. | 13209-41-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL (175.34 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Vamorolone 13209-41-1 Endocrinology/Hormones NF-Κb Glucocorticoid Receptor NF-κB inhibit repair Mineralocorticoid Receptor VBP 15 inflammation Duchenne Inhibitor membrane VBP15 dystrophy Nuclear factor-κB VBP-15 Nuclear factor-kappaB muscular glucocorticoid inhibitor