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MA-0204

Name: MA-0204
Brand: TargetMol
SKU: T15945
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15945Cas No. 2095128-17-7

MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively). It is a potential treatment for Duchene Muscular Dystrophy (DMD).

MA-0204

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Purity: 97.8%

Catalog No. T15945Cas No. 2095128-17-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	In Stock	In Stock
5 mg	$188	In Stock	In Stock
10 mg	$317	In Stock	In Stock
25 mg	$515	In Stock	In Stock
50 mg	$713	In Stock	In Stock
100 mg	$948	In Stock	In Stock
200 mg	$1,270	-	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.8%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively). It is a potential treatment for Duchene Muscular Dystrophy (DMD).
Targets&IC50	PPARδ:10 nM (EC50)(in rat), PPARδ:0.4 nM (EC50)(in human), PPARδ:7.9 nM (EC50)(in mouse)
In vitro	MA-0204 is >10,000-fold selective for activating PPARδ over PPARα and PPARγ receptors. At concentrations of 1.2-12 nM, MA-0204 enhances fatty acid oxidation in muscle myoblasts from DMD patients in mice, shows high protein binding in mouse plasma, exhibits good permeability, and has low potential for efflux. [C.]
In vivo	In the muscle, PPARδ (30, 100 mg/kg) enhances target gene transcription.

Chemical Properties

Molecular Weight	476.49
Formula	C₂₅H₂₇F₃N₂O₄
Cas No.	2095128-17-7
Smiles	C[C@H](CCCOc1ccccc1Cn1c(C)cnc1-c1ccc(OC(F)(F)F)cc1)CC(O)=O
Relative Density.	1.23 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (83.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (4.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0987 mL	10.4934 mL	20.9868 mL	104.9340 mL
5 mM	0.4197 mL	2.0987 mL	4.1974 mL	20.9868 mL
10 mM	0.2099 mL	1.0493 mL	2.0987 mL	10.4934 mL
20 mM	0.1049 mL	0.5247 mL	1.0493 mL	5.2467 mL
50 mM	0.0420 mL	0.2099 mL	0.4197 mL	2.0987 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc